ArticlePloS one2012
Early hemoperfusion may improve survival of severely paraquat-poisoned patients.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Continuous venovenous hemofiltration in the management of paraquat poisoning: A meta-analysis of randomized controlled trials.Medicine · 2017Pooled it
- The effects of ω-3 fish oil emulsion-based parenteral nutrition plus combination treatment for acute paraquat poisoning.The Journal of international medical research · 2019Trial
- Continuous plasma perfusion of dual cartridges in series: rationale and early clinical experience.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2016Trial
- Extracorporeal therapies in the management of paraquat poisoning: a comprehensive review of current evidence.Annals of medicine · 2026Review
- Indian Society of Critical Care Medicine Position Statement on the Management of Paraquat Poisoning.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2026Article
- Successful management of paraquat poisoning: a case report.Journal of medical case reports · 2025Article
- Fractionated plasma separation and adsorption integrated with continuous veno-venous hemofiltration in patients with acute bipyridine herbicide poisoning.Renal failure · 2024Article
- A hospital management algorithm for acute poisoning by Paraquat® in a pediatric population, a series of casesBiomedica : revista del Instituto Nacional de Salud · 2024Article
- Development and validation of a prognostic nomogram for predicting in-hospital mortality of patients with acute paraquat poisoning.Scientific reports · 2024Observational
- [Hemoperfusion in anesthesia and intensive care medicine: benefits, risks, and evidence for different systems].Die Anaesthesiologie · 2023Review
- Construction of a clinical nursing pathway for acute paraquat poisoning: Evidence-based research.Heliyon · 2023Article
- Cytokine changes in fatal cases of paraquat poisoning.American journal of translational research · 2021Article
- Article
- A Paper-Based Analytical Device for Analysis of Paraquat in Urine and Its Validation with Optical-Based Approaches.Diagnostics (Basel, Switzerland) · 2020Article
- Does Hemoperfusion Increase Survival in Acute Paraquat Poisoning? A Retrospective Multicenter Study.Toxics · 2020Article
- Osteonecrosis of Femoral Head, An Overlooked Long-Term Complication after Paraquat Intoxication: A Retrospective Cohort Study.Scientific reports · 2020Article
- Multiple organ dysfunction and rhabdomyolysis associated with moonwort poisoning: Report of four cases.World journal of clinical cases · 2020Article
- Two Potential Clinical Applications of Origami-Based Paper Devices.Diagnostics (Basel, Switzerland) · 2019Article
- The significance of serum HMGB1 level in humans with acute paraquat poisoning.Scientific reports · 2019Observational
- The Alexipharmic Mechanisms of Five Licorice Ingredients Involved in CYP450 and Nrf2 Pathways in Paraquat-Induced Mice Acute Lung Injury.Oxidative medicine and cellular longevity · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThousands of paraquat (PQ)-poisoned patients continue to die, particularly in developing countries. Although animal studies indicate that hemoperfusion (HP) within 2-4 h after intoxication effectively reduces mortality, the effect of early HP in humans remains unknown.
methodsWe analyzed the records of all PQ-poisoned patients admitted to 2 hospitals between 2000 and 2009. Patients were grouped according to early or late HP and high-dose (oral cyclophosphamide [CP] and intravenous dexamethasone [DX]) or repeated pulse (intravenous methylprednisolone [MP] and CP, followed by DX and repeated MP and/or CP) PQ therapy. Early HP was defined as HP <4 h, and late HP, as HP ≥ 4 h after PQ ingestion. We evaluated the associations between HP <4 h, <5 h, <6 h, and <7 h after PQ ingestion and the outcomes. Demographic, clinical, laboratory, and mortality data were analyzed.
resultsThe study included 207 severely PQ-poisoned patients. Forward stepwise multivariate Cox hazard regression analysis showed that early HP <4 h (hazard ratio [HR] = 0.38, 95% confidence interval (CI) 0.16-0.86; P = 0.020) or HP <5 h (HR = 0.60, 95% CI: 0.39-0.92; P = 0.019) significantly decreased the mortality risk. Further analysis showed that early HP reduced the mortality risk only in patients treated with repeated pulse therapy (n = 136), but not high-dose therapy (n = 71). Forward stepwise multivariate Cox hazard regression analysis showed that HP <4.0 h (HR = 0.19, 95% CI: 0.05-0.79; P = 0.022) or <5.0 h (HR = 0.49, 95% CI: 0.24-0.98; P = 0.043) after PQ ingestion significantly decreased the mortality risk in repeated pulse therapy patients, after adjustment for relevant variables.
conclusionThe results showed that early HP after PQ exposure might be effective in reducing mortality in severely poisoned patients, particularly in those treated with repeated pulse therapy.
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