ArticlePloS one2012
Prediction of C. elegans longevity genes by human and worm longevity networks.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Pooled it
- Meta-analysis on blood transcriptomic studies identifies consistently coexpressed protein-protein interaction modules as robust markers of human aging.Aging cell · 2014Pooled it
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- Expanding evolutionary theories of ageing to better account for symbioses and interactions throughout the Web of Life.Ageing research reviews · 2023Review
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- Knock-down ofAging · 2021Article
- Network analysis in aged C. elegans reveals candidate regulatory genes of ageing.Biogerontology · 2021Article
- Cross-Species and Human Inter-Tissue Network Analysis of Genes Implicated in Longevity and Aging Reveal Strong Support for Nutrient Sensing.Frontiers in genetics · 2021Article
- Bacterial diets differentially alter lifespan and healthspan trajectories in C. elegans.Communications biology · 2020Article
- SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes.Scientific data · 2020Article
- Gray whale transcriptome reveals longevity adaptations associated with DNA repair and ubiquitination.Aging cell · 2020Article
- Evolution of ageing as a tangle of trade-offs: energy versus function.Proceedings. Biological sciences · 2019Article
- Comparative transcriptomics across 14 Drosophila species reveals signatures of longevity.Aging cell · 2018Article
- The Energy Maintenance Theory of Aging: Maintaining Energy Metabolism to Allow Longevity.BioEssays : news and reviews in molecular, cellular and developmental biology · 2018Review
- Article
- Caenorhabditis elegans orthologs of human genes differentially expressed with age are enriched for determinants of longevity.Aging cell · 2017Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
Intricate and interconnected pathways modulate longevity, but screens to identify the components of these pathways have not been saturating. Because biological processes are often executed by protein complexes and fine-tuned by regulatory factors, the first-order protein-protein interactors of known longevity genes are likely to participate in the regulation of longevity. Data-rich maps of protein interactions have been established for many cardinal organisms such as yeast, worms, and humans. We propose that these interaction maps could be mined for the identification of new putative regulators of longevity. For this purpose, we have constructed longevity networks in both humans and worms. We reasoned that the essential first-order interactors of known longevity-associated genes in these networks are more likely to have longevity phenotypes than randomly chosen genes. We have used C. elegans to determine whether post-developmental inactivation of these essential genes modulates lifespan. Our results suggest that the worm and human longevity networks are functionally relevant and possess a high predictive power for identifying new longevity regulators.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.