ArticlePloS one2012
Statins and hip fracture prevention--a population based cohort study in women.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Efficacy of statins for osteoporosis: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Pooled it
- Effects of Statins on Bone Mineral Density and Fracture Risk: A PRISMA-compliant Systematic Review and Meta-Analysis.Medicine · 2016Pooled it
- Statin therapy and risk of fracture: results from the JUPITER randomized clinical trial.JAMA internal medicine · 2015Trial
- High-potency statins are associated with reduced osteoporosis but increased fracture risk in CKD patients: a multi-center retrospective study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Observational
- Article
- Age- and dose-dependent effect of statin use on the risk of osteoporotic fracture in older adults.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023Article
- Rationale and performances of a data-driven method for computing the duration of pharmacological prescriptions using secondary data sources.Scientific reports · 2022Article
- The associations of statin intake and the trabecular bone score and bone mineral density status in elderly Iranian individuals: a cross-sectional analysis of the Bushehr Elderly Health (BEH) program.Archives of osteoporosis · 2021Article
- Statin Therapy and the Risk of Osteoporotic Fractures in Patients with Metabolic Syndrome: a Nested Case-Control Study.Journal of lipid and atherosclerosis · 2021Article
- A Retrospective Study on Statins and Post-stroke Patients: What About Functional Outcome and Follow-Up in a Stroke Rehabilitation Cohort?Frontiers in neurology · 2021Article
- Is Switching from Oral Antidiabetic Therapy to Insulin Associated with an Increased Fracture Risk?Clinical orthopaedics and related research · 2020Article
- Methods for constructing treatment episodes and impact on exposure-outcome associations.European journal of clinical pharmacology · 2020Observational
- High-potency statins but not all statins decrease the risk of new-onset osteoporotic fractures: a nationwide population-based longitudinal cohort study.Clinical epidemiology · 2018Article
- Long-term effect of statins on the risk of new-onset osteoporosis: A nationwide population-based cohort study.PloS one · 2018Article
- Statin use and hip fractures in U.S. kidney transplant recipients.BMC nephrology · 2017Article
- Discontinuation of simvastatin leads to a rebound phenomenon and results in immediate peri-implant bone loss.Clinical and experimental dental research · 2016Article
- Article
- Statin use and risk of fracture: a meta-analysis.International journal of clinical and experimental medicine · 2015Article
- Melatonin potentiates the anti-tumour effect of pravastatin in rat mammary gland carcinoma model.International journal of experimental pathology · 2014Article
- Measurement of statin exposure in the absence of information on prescribed doses.European journal of clinical pharmacology · 2014Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo study the association of long-term statin use and the risk of low-energy hip fractures in middle-aged and elderly women.
designA register-based cohort study.
settingFinland.
participantsWomen aged 45-75 years initiating statin therapy between 1996 and 2001 with adherence to statins ≥ 80% during the subsequent five years (n = 40,254), a respective cohort initiating hypertension drugs (n = 41 610), and women randomly selected from the population (n = 62 585).
main outcome measuresIncidence rate of and hazard ratio (HR) for low-energy hip fracture during the follow-up extending up to 7 years after the 5-year exposure period.
resultsAltogether 199 low-energy hip fractures occurred during the 135 330 person-years (py) of follow-up in the statin cohort, giving an incidence rate of 1.5 hip fractures per 1000 py. In the hypertension and the population cohorts, the rates were 2.0 per 1000 py (312 fractures per 157,090 py) and 1.0 per 1000 py (212 fractures per 216 329 py), respectively. Adjusting for a propensity score and individual variables strongly predicting the outcome, good adherence to statins for five years was associated with a 29% decreased risk (HR 0.71; 95% CI 0.58-0.86) of a low-energy hip fracture in comparison with adherent use of hypertension drugs. The association was of the same magnitude when comparing the statin users with the population cohort, the HR being 0.69 (0.55-0.87). When women with poor (<40%), moderate (40 to 80%), and good adherence (≥ 80%) to statins were compared to those with good adherence to hypertension drugs (≥ 80%) or to the population cohort, the protective effect associated with statin use attenuated with the decreasing level of adherence.
conclusions5-year exposure to statins is associated with a reduced risk of low-energy hip fracture in women aged 50-80 years without prior hospitalizations for fractures.
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Registered trials
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