ArticlePLoS pathogens2012
Genome structure and reproductive behaviour influence the evolutionary potential of a fungal phytopathogen.
Article in PLoS pathogens, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
45 citing papers in PubMed, 155 citations in OpenAlex.
- Demography and Localized Reservoirs of Diversity Underlie Global Divergence in the Giant Kelp Macrocystis pyrifera.Molecular ecology · 2026Article
- MPSeqM, a tool combining multiplex PCR and high-throughput sequencing to study the polymorphism of eight Leptosphaeria maculans avirulence genes and its application to field surveys in France.BMC microbiology · 2025Article
- To be or not to be a nonhost species: A case study of the Leptosphaeria maculans and Brassica carinata interaction.Environmental microbiology reports · 2024Article
- Breeding and management of major resistance genes to stem canker/blackleg in Brassica crops.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Review
- Effects of pathogen reproduction system on the evolutionary and epidemiological control provided by deployment strategies for two major resistance genes in agricultural landscapes.Evolutionary applications · 2024Article
- The neighbouring genes AvrLm10A and AvrLm10B are part of a large multigene family of cooperating effector genes conserved in Dothideomycetes and Sordariomycetes.Molecular plant pathology · 2023Article
- Article
- Independent breakdown events of the Brassica napus Rlm7 resistance gene including via the off-target impact of a dual-specificity avirulence interaction.Molecular plant pathology · 2022Article
- A new family of structurally conserved fungal effectors displays epistatic interactions with plant resistance proteins.PLoS pathogens · 2022Article
- Efficacy of Blackleg Major Resistance Genes inPathogens (Basel, Switzerland) · 2022Article
- Association analysis of rice resistance genes and blast fungal avirulence genes for effective breeding resistance cultivars.Frontiers in microbiology · 2022Article
- A new avirulence gene of Leptosphaeria maculans, AvrLm14, identifies a resistance source in American broccoli (Brassica oleracea) genotypes.Molecular plant pathology · 2021Article
- A single amino acid polymorphism in a conserved effector of the multihost blast fungus pathogen expands host-target binding spectrum.PLoS pathogens · 2021Article
- Population-level deep sequencing reveals the interplay of clonal and sexual reproduction in the fungal wheat pathogenMicrobial genomics · 2021Article
- Genome-wide mapping of histone modifications during axenic growth in two species of Leptosphaeria maculans showing contrasting genomic organization.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2021Article
- Recent Findings Unravel Genes and Genetic Factors UnderlyingInternational journal of molecular sciences · 2020Review
- Effector gene silencing mediated by histone methylation underpins host adaptation in an oomycete plant pathogen.Nucleic acids research · 2020Article
- Generation and Characterization of a VirulentFrontiers in microbiology · 2020Article
- Repeat-Induced Point Mutations Drive Divergence betweenPathogens (Basel, Switzerland) · 2019Article
- Effector gene reshuffling involves dispensable mini-chromosomes in the wheat blast fungus.PLoS genetics · 2019Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Modern agriculture favours the selection and spread of novel plant diseases. Furthermore, crop genetic resistance against pathogens is often rendered ineffective within a few years of its commercial deployment. Leptosphaeria maculans, the cause of phoma stem canker of oilseed rape, develops gene-for-gene interactions with its host plant, and has a high evolutionary potential to render ineffective novel sources of resistance in crops. Here, we established a four-year field experiment to monitor the evolution of populations confronted with the newly released Rlm7 resistance and to investigate the nature of the mutations responsible for virulence against Rlm7. A total of 2551 fungal isolates were collected from experimental crops of a Rlm7 cultivar or a cultivar without Rlm7. All isolates were phenotyped for virulence and a subset was genotyped with neutral genetic markers. Virulent isolates were investigated for molecular events at the AvrLm4-7 locus. Whilst virulent isolates were not found in neighbouring crops, their frequency had reached 36% in the experimental field after four years. An extreme diversity of independent molecular events leading to virulence was identified in populations, with large-scale Repeat Induced Point mutations or complete deletion of AvrLm4-7 being the most frequent. Our data suggest that increased mutability of fungal genes involved in the interactions with plants is directly related to their genomic environment and reproductive system. Thus, rapid allelic diversification of avirulence genes can be generated in L. maculans populations in a single field provided that large population sizes and sexual reproduction are favoured by agricultural practices.
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