ArticlePLoS pathogens2012
Phenoloxidase activity acts as a mosquito innate immune response against infection with Semliki Forest virus.
Article in PLoS pathogens, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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Who cites it
67 citing papers in PubMed, 124 citations in OpenAlex.
- Antioxidant, Redox, and Immunomodulatory Effects ofBiomedicines · 2026Article
- Temporal and spatial profiling of Aedes albopictus immune responses to chikungunya virus infection.PLoS neglected tropical diseases · 2025Article
- High Quality Diet Enhances Immune Response and Affects Gene Expression During Viral Infection in an Insect Herbivore.Molecular ecology · 2025Article
- A Head-Specific Transcriptomic Study Reveals Key Regulatory Pathways for Winter Diapause in the Mosquito Culex pipiens.Archives of insect biochemistry and physiology · 2025Article
- An Overview of Zika Virus and Zika Virus Induced Neuropathies.International journal of molecular sciences · 2024Review
- Response of the mosquito immune system and symbiotic bacteria to pathogen infection.Parasites & vectors · 2024Review
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- A comprehensive review ofFrontiers in immunology · 2024Review
- Higher temperature accelerates the aging-dependent weakening of the melanization immune response in mosquitoes.PLoS pathogens · 2024Article
- Recognition of Arboviruses by the Mosquito Immune System.Biomolecules · 2023Review
- Article
- Prophenoloxidase ofInternational journal of molecular sciences · 2022Article
- Chronic depletion of vertebrate lipids in Aedes aegypti cells dysregulates lipid metabolism and inhibits innate immunity without altering dengue infectivity.PLoS neglected tropical diseases · 2022Article
- The Role of Mosquito Hemocytes in Viral Infections.Viruses · 2022Review
- Serpin-4 Facilitates Baculovirus Infection by Inhibiting Melanization in Asian Corn Borer,Frontiers in immunology · 2022Article
- Functional characterization of two clip domain serine proteases in innate immune responses of Aedes aegypti.Parasites & vectors · 2021Article
- Sugar feeding protects against arboviral infection by enhancing gut immunity in the mosquito vector Aedes aegypti.PLoS pathogens · 2021Article
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7 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors at 5 institutions in 3 countries.
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Abstract
Several components of the mosquito immune system including the RNA interference (RNAi), JAK/STAT, Toll and IMD pathways have previously been implicated in controlling arbovirus infections. In contrast, the role of the phenoloxidase (PO) cascade in mosquito antiviral immunity is unknown. Here we show that conditioned medium from the Aedes albopictus-derived U4.4 cell line contains a functional PO cascade, which is activated by the bacterium Escherichia coli and the arbovirus Semliki Forest virus (SFV) (Togaviridae; Alphavirus). Production of recombinant SFV expressing the PO cascade inhibitor Egf1.0 blocked PO activity in U4.4 cell- conditioned medium, which resulted in enhanced spread of SFV. Infection of adult female Aedes aegypti by feeding mosquitoes a bloodmeal containing Egf1.0-expressing SFV increased virus replication and mosquito mortality. Collectively, these results suggest the PO cascade of mosquitoes plays an important role in immune defence against arboviruses.
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