ArticleThe application of clinical genetics2012
Clinical applications of schizophrenia genetics: genetic diagnosis, risk, and counseling in the molecular era.
Article in The application of clinical genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 72 citations in OpenAlex.
- A pilot randomized clinical trial evaluating the impact of genetic counseling for serious mental illnesses.The Journal of clinical psychiatry · 2016Trial
- Developing genetic literacy in high school students with intellectual disability: Teachers' experiences and perspectives.European journal of human genetics : EJHG · 2025Article
- NGS Approaches in Clinical Diagnostics: From Workflow to Disease-Specific Applications.International journal of molecular sciences · 2025Review
- Perceptions of causal attribution and attitudes to genetic testing among people with schizophrenia and their first-degree relatives.European journal of human genetics : EJHG · 2022Article
- Schizophrenia-derived hiPSC brain microvascular endothelial-like cells show impairments in angiogenesis and blood-brain barrier function.Molecular psychiatry · 2022Article
- Psychiatric genetic counseling for patients with schizophrenia and their families.Frontiers in psychiatry · 2022Article
- PGx in psychiatry: Patients' knowledge, interest, and uncertainty management preferences in the context of pharmacogenomic testing.Patient education and counseling · 2021Article
- Genome-wide association study of psychiatric and substance use comorbidity in Mexican individuals.Scientific reports · 2021Article
- Genome sequencing broadens the range of contributing variants with clinical implications in schizophrenia.Translational psychiatry · 2021Article
- Psychiatric genomics researchers' perspectives on best practices for returning results to individual participants.Genetics in medicine : official journal of the American College of Medical Genetics · 2020Article
- Genetics and genetic counseling in psychiatry: Results from an opinion survey of professionals and users.Molecular genetics & genomic medicine · 2019Article
- Screening for rare epigenetic variations in autism and schizophrenia.Human mutation · 2019Article
- Women who suffer from schizophrenia: Critical issues.World journal of psychiatry · 2018Review
- Altered Expression Profile of IgLON Family of Neural Cell Adhesion Molecules in the Dorsolateral Prefrontal Cortex of Schizophrenic Patients.Frontiers in molecular neuroscience · 2018Article
- Genomic Disorders in Psychiatry-What Does the Clinician Need to Know?Current psychiatry reports · 2017Review
- Stratifying empiric risk of schizophrenia among first degree relatives using multiple predictors in two independent Indian samples.Asian journal of psychiatry · 2016Article
- Communication of Psychiatric Risk in 22q11.2 Deletion Syndrome: A Pilot Project.Journal of genetic counseling · 2016Article
- The human clinical phenotypes of altered CHRNA7 copy number.Biochemical pharmacology · 2015Review
- Disclosure of psychiatric manifestations of 22q11.2 deletion syndrome in medical genetics: A 12-year retrospective chart review.American journal of medical genetics. Part A · 2015Article
- Whole-Genome Sequencing Suggests Schizophrenia Risk Mechanisms in Humans with 22q11.2 Deletion Syndrome.G3 (Bethesda, Md.) · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Schizophrenia is a complex neuropsychiatric disease with documented clinical and genetic heterogeneity, and evidence for neurodevelopmental origins. Driven by new genetic technologies and advances in molecular medicine, there has recently been concrete progress in understanding some of the specific genetic causes of this serious psychiatric illness. In particular, several large rare structural variants have been convincingly associated with schizophrenia, in targeted studies over two decades with respect to 22q11.2 microdeletions, and more recently in large-scale, genome-wide case-control studies. These advances promise to help many families afflicted with this disease. In this review, we critically appraise recent developments in the field of schizophrenia genetics through the lens of immediate clinical applicability. Much work remains in translating the recent surge of genetic research discoveries into the clinic. The epidemiology and basic genetic parameters (such as penetrance and expression) of most genomic disorders associated with schizophrenia are not yet well characterized. To date, 22q11.2 deletion syndrome is the only established genetic subtype of schizophrenia of proven clinical relevance. We use this well-established association as a model to chart the pathway for translating emerging genetic discoveries into clinical practice. We also propose new directions for research involving general genetic risk prediction and counseling in schizophrenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.