Evidence map›Paper›PMID 23144350›Full record

ArticleBMJ case reports2012

Efficacy and cost of micronutrient treatment of childhood psychosis.

Megan Rodway, Annette Vance, Amany Watters, Helen Lee, Elske Bos, Bonnie J Kaplan

Abstract readCase Reports
In one paragraph

Article in BMJ case reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Megan RodwayDepartment of Psychiatry, University of Calgary, Calgary, Alberta, Canada.
Annette Vance
Amany Watters
Helen Lee
Elske Bos
Bonnie J Kaplan

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Psychosis is difficult to treat effectively with conventional pharmaceuticals, many of which have adverse long-term health consequences. In contrast, there are promising reports from several research groups of micronutrient treatment (vitamins, minerals, amino acids and essential fatty acids) of mood, anxiety and psychosis symptoms using a complex formula that appears to be safe and tolerable. We review previous studies using this formula to treat mental symptoms, and present an 11-year-old boy with a 3-year history of mental illness whose parents chose to transition him from medication to micronutrients. Symptom severity was monitored in three clusters: anxiety, obsessive compulsive disorder and psychosis. Complete remission of psychosis occurred, and severity of anxiety and obsessional symptoms decreased significantly (p<0.001); the improvements are sustained at 4-year follow-up. A cost comparison revealed that micronutrient treatment was <1% of his inpatient mental healthcare. Additional research on broad-spectrum micronutrient treatment is warranted.

Indexed as

Amino AcidsAnxiety DisordersChildCost-Benefit AnalysisFatty Acids, EssentialFollow-Up StudiesHumansMaleMicronutrientsMineralsObsessive-Compulsive DisorderPsychotic DisordersRemission InductionTrace ElementsTreatment OutcomeVitaminsAmino AcidsFatty Acids, EssentialMicronutrientsMineralsTrace ElementsVitamins

Identifiers

PMID23144350
PMCPMC4543964

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.