ArticleAmerican journal of physiology. Heart and circulatory physiology2013
Identification of a region of rat chromosome 1 that impairs the myogenic response and autoregulation of cerebral blood flow in fawn-hooded hypertensive rats.
Article in American journal of physiology. Heart and circulatory physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 19 citations in OpenAlex.
- The adducin saga: pleiotropic genomic targets for precision medicine in human hypertension-vascular, renal, and cognitive diseases.Physiological genomics · 2022Review
- Impaired renal hemodynamics and glomerular hyperfiltration contribute to hypertension-induced renal injury.American journal of physiology. Renal physiology · 2020Article
- Mechanisms of cognitive dysfunction in CKD.Nature reviews. Nephrology · 2020Review
- A Mutation inJournal of the American Society of Nephrology : JASN · 2020Article
- Knockout of Dual-Specificity Protein Phosphatase 5 Protects Against Hypertension-Induced Renal Injury.The Journal of pharmacology and experimental therapeutics · 2019Article
- Cerebral microhemorrhages: mechanisms, consequences, and prevention.American journal of physiology. Heart and circulatory physiology · 2017Review
- Knockdown of Add3 impairs the myogenic response of renal afferent arterioles and middle cerebral arteries.American journal of physiology. Renal physiology · 2017Article
- Cerebral Autoregulation in Hypertension and Ischemic Stroke: A Mini Review.Journal of pharmaceutical sciences and experimental pharmacology · 2017Article
- Elevated K+ channel activity opposes vasoconstrictor response to serotonin in cerebral arteries of the Fawn Hooded Hypertensive rat.Physiological genomics · 2017Article
- Endocannabinoids in cerebrovascular regulation.American journal of physiology. Heart and circulatory physiology · 2016Review
- Renal autoregulation in health and disease.Physiological reviews · 2015Review
- Impaired myogenic response and autoregulation of cerebral blood flow is rescued in CYP4A1 transgenic Dahl salt-sensitive rat.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- Elevated Aminopeptidase P Attenuates Cerebral Arterial Responses to Bradykinin in Fawn-Hooded Hypertensive Rats.PloS one · 2015Article
- Interleukin-1 and acute brain injury.Frontiers in cellular neuroscience · 2015Review
- Enhanced large conductance K+ channel activity contributes to the impaired myogenic response in the cerebral vasculature of Fawn Hooded Hypertensive rats.American journal of physiology. Heart and circulatory physiology · 2014Article
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9 authors at 2 institutions in 1 country.
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Abstract
This study examined the effects of transfer of a 2.4-Mbp region of rat chromosome 1 (RNO1) from Brown Norway (BN) into fawn-hooded hypertensive (FHH) rats on autoregulation (AR) of cerebral blood flow (CBF) and the myogenic response of middle cerebral arteries (MCAs). AR of CBF was poor in FHH and FHH.1(BN) AR(-) congenic strains that excluded the critical 2.4-Mbp region. In contrast, AR was restored in FHH.1(BN) AR(+) congenic strains that included this region. The diameter of MCAs of FHH rats increased from 140 ± 14 to 157 ± 18 μm when transmural pressure was increased from 40 to 140 mmHg, but it decreased from 137 ± 5 to 94 ± 7 μm in FHH.1(BN) AR(+) congenic strains. Transient occlusion of MCAs reduced CBF by 80% in all strains. However, the hyperemic response following ischemia was significantly greater in FHH and AR(-) rats than that seen in AR(+) congenic strains (AR(-), 173 ± 11% vs. AR(+), 124 ± 5%). Infarct size and edema formation were also significantly greater in an AR(-) strain (38.6 ± 2.6 and 12.1 ± 2%) than in AR(+) congenic strains (27.6 ± 1.8 and 6.5 ± 0.9%). These results indicate that there is a gene in the 2.4-Mbp region of RNO1 that alters the development of myogenic tone in cerebral arteries. Transfer of this region from BN to FHH rats restores AR of CBF and vascular reactivity and reduces cerebral injury after transient occlusion and reperfusion of the MCA.
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