ReviewJournal of bacteriology2013
Are there acyl-homoserine lactones within mammalian intestines?
Review in Journal of bacteriology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 61 citations in OpenAlex.
- The Quorum-Sensing Regulator SdiA ActivatesMicroorganisms · 2026Article
- Leveraging chemical synthesis to discover metabolites from the gut microbiome.Annals of the New York Academy of Sciences · 2025Review
- Role of the LuxR solo, SdiA, in eavesdropping on foreign bacteria.FEMS microbiology reviews · 2025Review
- From intestine to beyond:Open biology · 2024Article
- Quorum sensing modulates bacterial virulence and colonization dynamics of the gastrointestinal pathogenGut microbes · 2023Article
- Conversations in the Gut: The Role of Quorum Sensing in Normobiosis.International journal of molecular sciences · 2023Review
- Impact of IBD-Associated Dysbiosis on Bacterial Quorum Sensing Mediated by Acyl-Homoserine Lactone in Human Gut Microbiota.International journal of molecular sciences · 2022Article
- How does Quorum Sensing of Intestinal Bacteria Affect Our Health and Mental Status?Microorganisms · 2022Review
- 3-oxo-C12:2-HSL, quorum sensing molecule from human intestinal microbiota, inhibits pro-inflammatory pathways in immune cells via bitter taste receptors.Scientific reports · 2022Article
- Bile Salt Hydrolase Degrades β-Lactam Antibiotics and Confers Antibiotic Resistance onFrontiers in microbiology · 2022Article
- Gossip in the gut: Quorum sensing, a new player in the host-microbiota interactions.World journal of gastroenterology · 2021Review
- Detection of gut microbiota and pathogen produced N-acyl homoserine in host circulation and tissues.NPJ biofilms and microbiomes · 2021Article
- Investigation of the invasion mechanism mediated by the outer membrane protein PagN of Salmonella Typhimurium.BMC microbiology · 2021Article
- Impact ofFrontiers in immunology · 2020Review
- Article
- How Can We Define "Optimal Microbiota?": A Comparative Review of Structure and Functions of Microbiota of Animals, Fish, and Plants in Agriculture.Frontiers in nutrition · 2018Review
- Isolation and Characterization of N-acyl Homoserine Lactone-Producing Bacteria From Cattle Rumen and Swine Intestines.Frontiers in cellular and infection microbiology · 2018Article
- Expression profiling of Tas2r genes reveals a complex pattern along the mouse GI tract and the presence of Tas2r131 in a subset of intestinal Paneth cells.Cellular and molecular life sciences : CMLS · 2018Article
- Biochemical Mechanisms of Pathogen Restriction by Intestinal Bacteria.Trends in biochemical sciences · 2017Review
- Quorum Sensing N-acyl Homoserine Lactones-SdiA SuppressesFrontiers in cellular and infection microbiology · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Many Proteobacteria are capable of quorum sensing using N-acyl-homoserine lactone (acyl-HSL) signaling molecules that are synthesized by LuxI or LuxM homologs and detected by transcription factors of the LuxR family. Most quorum-sensing species have at least one LuxR and one LuxI homolog. However, members of the Escherichia, Salmonella, Klebsiella, and Enterobacter genera possess only a single LuxR homolog, SdiA, and no acyl-HSL synthase. The most obvious hypothesis is that these organisms are eavesdropping on acyl-HSL production within the complex microbial communities of the mammalian intestinal tract. However, there is currently no evidence of acyl-HSLs being produced within normal intestinal communities. A few intestinal pathogens, including Yersinia enterocolitica, do produce acyl-HSLs, and Salmonella can detect them during infection. Therefore, a more refined hypothesis is that SdiA orthologs are used for eavesdropping on other quorum-sensing pathogens in the host. However, the lack of acyl-HSL signaling among the normal intestinal residents is a surprising finding given the complexity of intestinal communities. In this review, we examine the evidence for and against the possibility of acyl-HSL signaling molecules in the mammalian intestine and discuss the possibility that related signaling molecules might be present and awaiting discovery.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.