Trial reportPediatric pulmonology2013
Obesity in children with poorly controlled asthma: Sex differences.
Trial report in Pediatric pulmonology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Overweight, Obesity, and Lung Function in Children and Adults-A Meta-analysis.The journal of allergy and clinical immunology. In practicePooled it
- Sex, hormones, and lung health.Physiological reviews · 2026Review
- Risk behaviours and non-atopic comorbidities of adolescents with asthma.The World Allergy Organization journal · 2025Article
- Associations between overweight and obesity and asthma outcomes in urban adolescents.The Journal of asthma : official journal of the Association for the Care of Asthma · 2020Article
- Review
- Gender disparity in pediatrics: a review of the current literature.Italian journal of pediatrics · 2018Review
- [Effect of obesity on pulmonary function in asthmatic children of different age groups].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2017Article
- Atopy, but not obesity is associated with asthma severity among children with persistent asthma.The Journal of asthma : official journal of the Association for the Care of Asthma · 2016Article
- Sex differences in the association between neck circumference and asthma.Pediatric pulmonology · 2016Observational
- Severe asthma in school-age children: evaluation and phenotypic advances.Current allergy and asthma reports · 2015Review
- Overweight children report qualitatively distinct asthma symptoms: analysis of validated symptom measures.The Journal of allergy and clinical immunology · 2015Article
- An elevated body mass index increases lung volume but reduces airflow in Italian schoolchildren.PloS one · 2015Article
- Obesity and asthma in children: current and future therapeutic options.Paediatric drugs · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundObesity increases asthma risk, and may alter asthma severity. In adults, sex appears to modify the effect of obesity on asthma. Among children, the effect of sex on the relationship between obesity and asthma severity remains less clear, particularly when considering race.
objectiveTo determine how obesity affects disease characteristics in a diverse cohort of children with poorly controlled asthma, and if obesity effects are altered by sex.
designWe analyzed 306 children between 6 and 17 years of age with poorly controlled asthma enrolled in a 6-month trial assessing lansoprazole for asthma control. In this secondary analysis, we determined associations between obesity and symptom severity, spirometry, exacerbation risk, airway biomarkers, bronchial reactivity, and airflow perception. We used both a multivariate linear regression and longitudinal mixed-effect model to determine if obesity interacted with sex to affect asthma severity.
resultsRegardless of sex, BMI >95th percentile did not affect asthma control, exacerbation risk or airway biomarkers. Sex changed the effect of obesity on lung function (sex × obesity FEV1%, interaction P-value < 0.01, sex × obesity FEV1/FVC, interaction P-value = 0.03). Obese males had significantly worse airflow obstruction compared to non-obese males, while in females there was no obesity effect on airflow obstruction. In females, obesity was associated with significantly greater FEV1 and FVC, and a trend toward reduced airway reactivity.
conclusionsObesity did not affect asthma control, airway markers or disease stability; however obesity did affect lung function in a sex-dependent manner. In males, obesity associated with reduced FEV1/FVC, and in females, obesity associated with substantially improved lung function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.