ArticleMolecular nutrition & food research2013
The relationship between intracellular and plasma levels of folate and metabolites in the methionine cycle: a model.
Article in Molecular nutrition & food research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Replacing dietary animal-source proteins with plant-source proteins changes dietary intake and status of vitamins and minerals in healthy adults: a 12-week randomized controlled trial.European journal of nutrition · 2022Trial
- Sex-specific association of plasma vitamin E with homocysteine concentrations in Chinese middle-aged and older men and women: evidence from pooled population-based study.European journal of nutrition · 2026Article
- NNature reviews. Cancer · 2026Review
- Longitudinal Analysis of One-Carbon Metabolism-Related Metabolites in Maternal and Cord Blood of Japanese Pregnant Women.Nutrients · 2024Article
- Article
- Serum 5-Methyltetrahydrofolate Status Is Associated with One-Carbon Metabolism-Related Metabolite Concentrations and Enzyme Activity Indicators in Young Women.International journal of molecular sciences · 2023Article
- Review
- Altered Follicular Fluid Metabolic Pattern Correlates with Female Infertility and Outcome Measures of In Vitro Fertilization.International journal of molecular sciences · 2021Article
- Metabolic Control of mMetabolites · 2021Review
- Epigenetic Histone Modifications in the Pathogenesis of Diabetic Kidney Disease.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Review
- DNA methylation patterns of LINE-1 and Alu for pre-symptomatic dementia in type 2 diabetes.PloS one · 2020Article
- Perspective: Advancing Understanding of Population Nutrient-Health Relations via Metabolomics and Precision Phenotypes.Advances in nutrition (Bethesda, Md.) · 2019Article
- Epigenetics in Human Obesity and Type 2 Diabetes.Cell metabolism · 2019Review
- Mathematical modeling of the methionine cycle and transsulfuration pathway in individuals with autism spectrum disorder.Journal of theoretical biology · 2017Article
- Linking Pesticide Exposure with Pediatric Leukemia: Potential Underlying Mechanisms.International journal of molecular sciences · 2016Review
- Serum S-adenosylmethionine, but not methionine, increases in response to overfeeding in humans.Nutrition & diabetes · 2016Article
- One-carbon metabolism and epigenetics: understanding the specificity.Annals of the New York Academy of Sciences · 2016Review
- Association of folate and other one-carbon related nutrients with hypermethylation status and expression of RARB, BRCA1, and RASSF1A genes in breast cancer patients.Journal of molecular medicine (Berlin, Germany) · 2015Article
- Interaction of plasma glutathione redox and folate deficiency on arsenic methylation capacity in Bangladeshi adults.Free radical biology & medicine · 2014Article
- A population model of folate-mediated one-carbon metabolism.Nutrients · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
scopeFolate status and the status of the methionine cycle are typically assessed by measuring folate and metabolites in the plasma. It is assumed that plasma metabolite levels are proportional to their levels in tissues, but there is little information to support this assumption. METHODS AND
resultsWe developed a mathematical model, based on known kinetics of the methionine cycle in the liver and tissues, and the transport kinetics of metabolites into and out of the plasma. We use the model to explore the relationship between folate status and metabolite values in the plasma, the relationships between metabolite values and methylation capacity, the response to a methionine load, and the half-life of folate in plasma and tissues. We also use the model to study the effects of Down syndrome and oxidative stress on metabolite values in plasma and tissues. The model accurately reproduces measured metabolite values pre- and post-folate fortification. The model shows that a high acute intake of folate remains largely restricted to the plasma and is rapidly excreted; only a prolonged exposure to increased folate elevates tissue folate significantly.
conclusionThe model accurately reproduces experimental and clinical findings and can serve as a platform to study, in silico, the relationships between metabolite values in tissues and plasma, and how these vary with methionine and B vitamin input, and with mutations in the genes for enzymes in the methionine cycle.
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