ArticleDigestive diseases and sciences2013
Grape seed extract reduces the severity of selected disease markers in the proximal colon of dextran sulphate sodium-induced colitis in rats.
Article in Digestive diseases and sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 72 citations in OpenAlex.
- Fruitful Interventions: A Narrative Review Addressing the Emerging Role of Antioxidant Fruits in Combating IBD-Driven Colorectal Cancer.Mini reviews in medicinal chemistry · 2026Review
- Advances in oral treatment of inflammatory bowel disease using protein-based nanoparticle drug delivery systems.Drug delivery · 2025Review
- From Nature to Innovation: The Uncharted Potential of Natural Deep Eutectic Solvents.Molecules (Basel, Switzerland) · 2023Review
- A grape (Vitis vinifera L.) pomace water extract modulates inflammatory and immune response in SW-480 cells and isolated mouse colon.Phytotherapy research : PTR · 2022Article
- Grape seed and skin extract, a potential prebiotic with anti-obesity effect through gut microbiota modulation.Gut pathogens · 2022Article
- Grape seed powder increases gastrointestinal motility.International journal of medical sciences · 2022Article
- The Concentration of Organic Acids in Cranberry Juice Modulates the Gut Microbiota in Mice.International journal of molecular sciences · 2021Article
- Effects of Wine Components in Inflammatory Bowel Diseases.Molecules (Basel, Switzerland) · 2021Review
- Protective properties of grape-seed proanthocyanidins in human ex vivo acute colonic dysfunction induced by dextran sodium sulfate.European journal of nutrition · 2021Article
- Genome-Wide Regulation of Acupuncture and Moxibustion on Ulcerative Colitis Rats.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Supplementation of Kiwifruit Polyphenol Extract Attenuates High Fat Diet Induced Intestinal Barrier Damage and Inflammation via Reshaping Gut Microbiome.Frontiers in nutrition · 2021Article
- Potential of the ellagic acid-derived gut microbiota metabolite - Urolithin A in gastrointestinal protection.World journal of gastroenterology · 2020Review
- Proanthocyanidin-rich grape seed extract improves bone loss, bone healing, and implant osseointegration in ovariectomized animals.Scientific reports · 2020Article
- Antitumor Drug Combretastatin-A4 Phosphate Aggravates the Symptoms of Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice.Frontiers in pharmacology · 2020Article
- Aqueous Extract of Brazilian Berry (Nutrients · 2019Article
- Flightless I exacerbation of inflammatory responses contributes to increased colonic damage in a mouse model of dextran sulphate sodium-induced ulcerative colitis.Scientific reports · 2019Article
- The Gastrointestinal Tract as a Key Target Organ for the Health-Promoting Effects of Dietary Proanthocyanidins.Frontiers in nutrition · 2016Review
- Cytoprotective effects of grape seed extract on human gingival fibroblasts in relation to its antioxidant potential.PloS one · 2015Article
- A traditional Japanese medicine--Hangeshashinto (TJ-14)--alleviates chemoradiation-induced mucositis and improves rates of treatment completion.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2015Article
- Dietary agents and phytochemicals in the prevention and treatment of experimental ulcerative colitis.Journal of traditional and complementary medicine · 2014Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGrape seed extract (GSE) constitutes a rich source of procyanidins. GSE has been demonstrated to exert encouraging anti-inflammatory and anti-ulcer properties in experimental settings, although its effects on inflammation of the colon remain undefined.
aimTo determine the effects of GSE in a rat model of dextran sulphate sodium (DSS) for ulcerative colitis.
methodsMale Sprague-Dawley rats were gavaged daily (days 0-10) with GSE (400 mg/kg). Ulcerative colitis was induced by substituting DSS (2 % w/v) for drinking water from days 5-10. A sucrose breath test was performed on day 11 to determine small bowel function and intestinal tissues were collected for histological analyses. Statistical analysis was by one-way or repeated-measures ANOVA and p < 0.05 was considered significant.
resultsCompared to DSS-treated controls, GSE significantly decreased ileal villus height (14 %; p < 0.01) and mucosal thickness (13 %; p < 0.01) towards the values of normal controls. GSE reduced qualitative histological severity score (p < 0.05) in the proximal colon, although no significant effect was evident in the distal colon. However, GSE failed to prevent DSS-induced damage to the crypts of both colonic regions. Administration of GSE did not negatively impact metabolic parameters, nor did it induce any deleterious gastrointestinal side effects in healthy animals.
conclusionsGSE decreased the severity of selected markers of DSS-induced colitis in the distal ileum and proximal colon, suggesting the potential as an adjuvant therapy for the treatment of ulcerative colitis. Future studies of GSE should investigate alternative delivery methods and treatment regimens, further seeking to identify the individual bioactive factors.
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