ArticleExtremophiles : life under extreme conditions2013
Extreme zinc tolerance in acidophilic microorganisms from the bacterial and archaeal domains.
Article in Extremophiles : life under extreme conditions, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 64 citations in OpenAlex.
- Fluoride toxicity and mitigation strategies in acidophilic bioleaching microorganisms.Applied microbiology and biotechnology · 2026Article
- TroR is the primary regulator of the iron homeostasis transcription network in the halophilic archaeon Haloferax volcanii.Nucleic acids research · 2024Article
- Insertion sequence contributes to the evolution and environmental adaptation of Acidithiobacillus.BMC genomics · 2023Article
- Bioleaching of Heavy Metals from Printed Circuit Boards with an Acidophilic Iron-Oxidizing Microbial Consortium in Stirred Tank Reactors.Bioengineering (Basel, Switzerland) · 2022Article
- Article
- Can moderate heavy metal soil contaminations due to cement production influence the surrounding soil bacterial communities?Ecotoxicology (London, England) · 2022Article
- Molecular Mechanism of Nramp-Family Transition Metal Transport.Journal of molecular biology · 2021Review
- Forced Biomineralization: A Review.Biomimetics (Basel, Switzerland) · 2021Review
- Marine Actinomycetes, New Sources of Biotechnological Products.Marine drugs · 2021Review
- Processing of Metals and Metalloids byMicroorganisms · 2020Review
- Spatial Distribution of Toxic Metal(loid)s and Microbial Community Analysis in Soil Vertical Profile at an Abandoned Nonferrous Metal Smelting Site.International journal of environmental research and public health · 2020Article
- Metagenomic and Metatranscriptomic Study of Microbial Metal Resistance in an Acidic Pit Lake.Microorganisms · 2020Article
- Understanding Stress Response to High-Arsenic Gold-Bearing Sulfide Concentrate in Extremely Metal-Resistant AcidophileMicroorganisms · 2020Article
- Microorganisms and Their Metabolic Capabilities in the Context of the Biogeochemical Nitrogen Cycle at Extreme Environments.International journal of molecular sciences · 2020Review
- Sulfobacillus thermotolerans: new insights into resistance and metabolic capacities of acidophilic chemolithotrophs.Scientific reports · 2019Article
- Marine ArchaeonFrontiers in microbiology · 2019Article
- Genomic Insights Into the Acid Adaptation of Novel Methanotrophs Enriched From Acidic Forest Soils.Frontiers in microbiology · 2018Article
- Microbial copper resistance: importance in biohydrometallurgy.Microbial biotechnology · 2017Review
- Players over the Surface: Unraveling the Role of Exopolysaccharides in Zinc Biosorption by FluorescentFrontiers in microbiology · 2017Article
- Comparative Transcriptomic Analysis of the Response of Dunaliella acidophila (Chlorophyta) to Short-Term Cadmium and Chronic Natural Metal-Rich Water Exposures.Microbial ecology · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zinc can occur in extremely high concentrations in acidic, heavy metal polluted environments inhabited by acidophilic prokaryotes. Although these organisms are able to thrive in such severely contaminated ecosystems their resistance mechanisms have not been well studied. Bioinformatic analysis of a range of acidophilic bacterial and archaeal genomes identified homologues of several known zinc homeostasis systems. These included primary and secondary transporters, such as the primary heavy metal exporter ZntA and Nramp super-family secondary importer MntH. Three acidophilic model microorganisms, the archaeon 'Ferroplasma acidarmanus', the Gram negative bacterium Acidithiobacillus caldus, and the Gram positive bacterium Acidimicrobium ferrooxidans, were selected for detailed analyses. Zinc speciation modeling of the growth media demonstrated that a large fraction of the free metal ion is complexed, potentially affecting its toxicity. Indeed, many of the putative zinc homeostasis genes were constitutively expressed and with the exception of 'F. acidarmanus' ZntA, they were not up-regulated in the presence of excess zinc. Proteomic analysis revealed that zinc played a role in oxidative stress in At. caldus and Am. ferrooxidans. Furthermore, 'F. acidarmanus' kept a constant level of intracellular zinc over all conditions tested whereas the intracellular levels increased with increasing zinc exposure in the remaining organisms.
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