ArticleIEEE transactions on ultrasonics, ferroelectrics, and frequency control2012
Intravascular ultrasound catheter to enhance microbubble-based drug delivery via acoustic radiation force.
Article in IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Progress and potential of nanobubbles for ultrasound-mediated drug delivery.Expert opinion on drug delivery · 2025Review
- Exosomes and ultrasound: The future of theranostic applications.Materials today. Bio · 2023Review
- Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications.Beilstein journal of nanotechnology · 2021Review
- Micro/nano-bubble-assisted ultrasound to enhance the EPR effect and potential theranostic applications.Theranostics · 2020Review
- New Aspects of Ultrasound-Mediated Targeted Delivery and Therapy for Cancer.International journal of nanomedicine · 2020Review
- Pulsatile Drug Delivery System Triggered by Acoustic Radiation Force.Frontiers in bioengineering and biotechnology · 2020Article
- Reducing Neointima Formation in a Swine Model with IVUS and Sirolimus Microbubbles.Annals of biomedical engineering · 2015Article
- Localized in vivo model drug delivery with intravascular ultrasound and microbubbles.Ultrasound in medicine & biology · 2014Article
- An IVUS transducer for microbubble therapies.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2014Article
- Ultrasonic enhancement of drug penetration in solid tumors.Frontiers in oncology · 2013Article
- Dual-mode IVUS catheter for intracranial image-guided hyperthermia: feasibility study.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2010Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Previous research has demonstrated that acoustic radiation force enhances intravascular microbubble adhesion to blood vessels in the presence of flow for moleculartargeted ultrasound imaging and drug delivery. A prototype acoustic radiation force intravascular ultrasound (ARFIVUS) catheter was designed and fabricated to displace a microbubble contrast agent in flow representative of conditions encountered in the human carotid artery. The prototype ARFIVUS transducer was designed to match the resonance frequency of 1.4- to 2.6-μm-diameter microbubbles modeled by an experimentally verified 1-D microbubble acoustic radiation force translation model. The transducer element was an elongated Navy Type I (hard) lead zirconate titanate (PZT) ceramic designed to operate at 3 MHz. Fabricated devices operated with center frequencies of 3.3 and 3.6 MHz with -6-dB fractional bandwidths of 55% and 50%, respectively. Microbubble translation velocities as high as 0.86 m/s were measured using a high-speed streak camera when insonating with the ARFIVUS transducer. Finally, the prototype was used to displace microbubbles in a flow phantom while imaging with a commercial 45-MHz imaging IVUS transducer. A sustained increase of 31 dB in average video intensity was measured following insonation with the ARFIVUS, indicating microbubble accumulation resulting from the application of acoustic radiation force.
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Registered trials
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