ArticleBrain structure & function2013
The rostral subcommissural ventral pallidum is a mix of ventral pallidal neurons and neurons from adjacent areas: an electrophysiological study.
Article in Brain structure & function, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 44 citations in OpenAlex.
- Unpacking Ventral Pallidum GABA Neuron Contributions to Opioid Drug Reward in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Ventral pallidum GABA neuron inhibition augments context-appropriate defensive responses to learned threat cues.Neurobiology of stress · 2026Article
- Single-cell sequencing of rodent ventral pallidum reveals diverse neuronal subtypes with noncanonical interregional continuity.Science advances · 2025Article
- A ventral pallidal glutamatergic aversive network encodes abstinence from and reexposure to cocaine.Science advances · 2025Article
- Transcriptomic landscape of mammalian ventral pallidum at single-cell resolution.Science advances · 2024Article
- Ventral pallidum GABA and glutamate neurons drive approach and avoidance through distinct modulation of VTA cell types.Nature communications · 2024Article
- Ventral pallidum GABA and glutamate neurons drive approach and avoidance through distinct modulation of VTA cell types.bioRxiv : the preprint server for biology · 2023Article
- Ventral pallidal regulation of motivated behaviors and reinforcement.Frontiers in neural circuits · 2023Review
- Ventral pallidum GABA neurons bidirectionally control opioid relapse across rat behavioral models.Addiction neuroscience · 2022Article
- Astrocytes in the ventral pallidum extinguish heroin seeking through GAT-3 upregulation and morphological plasticity at D1-MSN terminals.Molecular psychiatry · 2022Article
- Circuit selectivity in drug versus natural reward seeking behaviors.Journal of neurochemistry · 2021Review
- Ventral Pallidum GABA Neurons Mediate Motivation Underlying Risky Choice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Ventral pallidum neurons dynamically signal relative threat.Communications biology · 2021Article
- Metaplasticity in the Ventral Pallidum as a Potential Marker for the Propensity to Gain Weight in Chronic High-Calorie Diet.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- 'Liking' and 'wanting' in eating and food reward: Brain mechanisms and clinical implications.Physiology & behavior · 2020Review
- Cocaine Dysregulates Dynorphin Modulation of Inhibitory Neurotransmission in the Ventral Pallidum in a Cell-Type-Specific Manner.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Projection-Specific Potentiation of Ventral Pallidal Glutamatergic Outputs after Abstinence from Cocaine.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Complementary Roles for Ventral Pallidum Cell Types and Their Projections in Relapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Neural circuits linking sleep and addiction: Animal models to understand why select individuals are more vulnerable to substance use disorders after sleep deprivation.Neuroscience and biobehavioral reviews · 2020Review
- Glutamatergic Ventral Pallidal Neurons Modulate Activity of the Habenula-Tegmental Circuitry and Constrain Reward Seeking.Biological psychiatry · 2018Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The ventral pallidum (VP) is a part of the ventral striatopallidal system and is involved in reward-related behaviors. The VP is composed of a ventromedial (VPvm) and a dorsolateral (VPdl) subregion, and some rostral-caudal differences are reported. Study of the VP often focuses on the subcommissural VP, typically considered homogenous in spite of known subdivisions. In this work, we used slice electrophysiology combined with immunohistochemistry for marker neuropeptides to test whether the subcommissural VP is functionally homogenous. Using sagittal slices, we show that more lateral levels (2.40 mm) of the subcommissural VP are homogenous but that a more medial slice (1.90 mm) contains two types of neurons. One type, located more caudally, resembles neurons in the lateral subcommissural VP, with long aspiny dendrites, primarily GABAergic input, and characteristic electrophysiological properties, such as depolarized membrane potential and spontaneous action potential discharge. The second type of neuron, located mostly in the rostral subcommissural VP, shows properties that are akin to medium spiny neurons of adjacent regions, including spiny dendrites, major glutamatergic input, hyperpolarized membrane potential, and no spontaneous action potentials. The two types of neurons were present in both the VPvm and VPdl, implying that the mix is not a characteristic of histologically defined subregions. We conclude that at medial levels the rostral subcommissural VP contains a mix of typical ventral pallidal neurons and spiny neurons similar to those in adjacent regions. This observation needs to be considered when interpreting past experiments and designing future experiments in the subcommissural VP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.