Evidence map›Paper›PMID 23143331›Full record

ReviewIntensive care medicine2013

Use of high flow nasal cannula in critically ill infants, children, and adults: a critical review of the literature.

Jan Hau Lee, Kyle J Rehder, Lee Williford, Ira M Cheifetz, David A Turner

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Publisher
In one paragraph

Review in Intensive care medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02793674 (High-Flow Nasal Cannula Flow Titration and Effort of Breathing in the Pediatric Intensive Care Unit), which is not on this map. Cited by 126 papers, 20 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
126citing papers in PubMed, 20 pooled it
19.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02793674 nacompletednot on this mapstarted 2014, after this paper: background citation

High-Flow Nasal Cannula Flow Titration and Effort of Breathing in the Pediatric Intensive Care Unit

TypeinterventionalSponsorChildren's Hospital Los AngelesRan2014 to 2016Enrolled21ConditionsHigh Flow Nasal CannulaArmsFisher & Paykel high flow nasal cannula, Vapotherm high flow nasal cannula
3 · Its place in the literature

Who cites it

126 citing papers in PubMed, 20 syntheses or guidelines pooled it, 388 citations in OpenAlex.

  1. Pooled it
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  3. High-flow nasal cannula therapy for infants with bronchiolitis.The Cochrane database of systematic reviews · 2024
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  8. Noninvasive respiratory support after extubation: a systematic review and network meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2023
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  9. Guideline
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  19. High-flow nasal cannula therapy for respiratory support in children.The Cochrane database of systematic reviews · 2014
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  20. High-flow nasal cannula therapy for infants with bronchiolitis.The Cochrane database of systematic reviews · 2014
    Pooled it

66 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Jan Hau LeeDivision of Pediatric Critical Care Medicine, Department of Pediatrics, Duke Children's Hospital, Durham, NC, USA. leejanhau@gmail.com
Kyle J Rehder
Lee Williford
Ira M Cheifetz
David A Turner
Duke Children's Hospital & Health Center · USDuke Medical Center · USDuke University Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHigh flow nasal cannula (HFNC) systems utilize higher gas flow rates than standard nasal cannulae. The use of HFNC as a respiratory support modality is increasing in the infant, pediatric, and adult populations as an alternative to non-invasive positive pressure ventilation.

objectivesThis critical review aims to: (1) appraise available evidence with regard to the utility of HFNC in neonatal, pediatric, and adult patients; (2) review the physiology of HFNC; (3) describe available HFNC systems (online supplement); and (4) review ongoing and planned trials studying the utility of HFNC in various clinical settings.

resultsClinical neonatal studies are limited to premature infants. Only a few pediatric studies have examined the use of HFNC, with most focusing on this modality for viral bronchiolitis. In critically ill adults, most studies have focused on acute respiratory parameters and short-term physiologic outcomes with limited investigations focusing on clinical outcomes such as duration of therapy and need for escalation of ventilatory support. Current evidence demonstrates that HFNC generates positive airway pressure in most circumstances; however, the predominant mechanism of action in relieving respiratory distress is not well established.

conclusionCurrent evidence suggests that HFNC is well tolerated and may be feasible in a subset of patients who require ventilatory support with non-invasive ventilation. However, HFNC has not been demonstrated to be equivalent or superior to non-invasive positive pressure ventilation, and further studies are needed to identify clinical indications for HFNC in patients with moderate to severe respiratory distress.

Indexed as

Critical IllnessAdultCathetersChildHumansInfantNoninvasive VentilationNose

Identifiers

PMID23143331
OpenAlexW2074471445

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.