ArticleThe EMBO journal2012
Transcriptional repression of the APC/C activator CCS52A1 promotes active termination of cell growth.
Article in The EMBO journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 73 citations in OpenAlex.
- Molecular regulation of plant endoreduplication: core mechanisms and their upstream control.Plant molecular biology · 2026Review
- Genome-wide identification of the GT transcription factor family in alfalfa and functional characterization of MsGT16 in salt stress tolerance.BMC genomics · 2026Article
- The endocycle regulators SIM and CCS52A1 control Arabidopsis root hair cell ploidy and expansion.Plant physiology · 2025Article
- A map of integrated cis-regulatory elements enhances gene-regulatory analysis in maize.Plant communications · 2025Article
- USP8 and Hsp70 regulate endoreplication by synergistically promoting Fzr deubiquitination and stabilization.Science advances · 2025Article
- Carnivorous Nepenthes pitcher plants combine common developmental processes to make a complex epidermal trapping surface.Annals of botany · 2025Article
- Cullin-Conciliated Regulation of Plant Immune Responses: Implications for Sustainable Crop Protection.Plants (Basel, Switzerland) · 2024Review
- Transcriptional repression ofPlant direct · 2024Article
- Article
- Trihelix transcription factors GTL1 and DF1 prevent aberrant root hair formation in an excess nutrient condition.The New phytologist · 2022Article
- The role of APC/C in cell cycle dynamics, growth and development in cereal crops.Frontiers in plant science · 2022Review
- Phytohormone-Based Regulation of Trichome Development.Frontiers in plant science · 2021Review
- The Tomato Guanylate-Binding Protein SlGBP1 Enables Fruit Tissue Differentiation by Maintaining Endopolyploid Cells in a Non-Proliferative State.The Plant cell · 2020Article
- Molecular networks regulating cell division during Arabidopsis leaf growth.Journal of experimental botany · 2020Review
- Genome-wide MNase hypersensitivity assay unveils distinct classes of open chromatin associated with H3K27me3 and DNA methylation in Arabidopsis thaliana.Genome biology · 2020Article
- Transcriptional Repression of the APC/C Activator GenesThe Plant cell · 2019Article
- The Dynamic Genetic-Hormonal Regulatory Network Controlling the Trichome Development in Leaves.Plants (Basel, Switzerland) · 2019Review
- A gene regulatory network for root hair development.Journal of plant research · 2019Review
- The Trihelix transcription factor GT2-like 1 (GTL1) promotes salicylic acid metabolism, and regulates bacterial-triggered immunity.PLoS genetics · 2018Article
- GTL1 and DF1 regulate root hair growth through transcriptional repression ofDevelopment (Cambridge, England) · 2018Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spatial and temporal control of cell growth is central for the morphogenesis of multicellular organisms. For some cell types that undergo extensive post-mitotic cell growth, such as neurons and hair cells, orchestrating the extent of post-mitotic cell growth with development is vital for their physiology and function. Previous studies suggested that the extent of cell growth is linked with an increase in ploidy by endoreduplication but how developmental signals control endocycling and cell growth is not understood in both animals and plants. In this study we show that a trihelix transcription factor, GT2-LIKE 1 (GTL1), actively terminates ploidy-dependent cell growth and its developmentally regulated expression is one of the key determinants of cell size in Arabidopsis leaf hair cells (trichomes). Through genome-wide chromatin-binding studies (ChIP-chip) coupled with transcriptional profiling, we further demonstrate that GTL1 directly represses the transcription of CDH1/FZR/CCS52, an activator of the anaphase-promoting complex/cyclosome (APC/C), to stop the endocycle progression and ploidy-dependent cell growth. Thus, our findings uncover a previously uncharacterised key molecular link between developmental programming and cell-size control, highlighting the central role of APC/C in post-mitotic cell growth.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.