Evidence map›Paper›PMID 23143106›Full record

ArticleNucleic acids research2013

EcoCyc: fusing model organism databases with systems biology.

Ingrid M Keseler, Amanda Mackie, Martin Peralta-Gil, Alberto Santos-Zavaleta, Socorro Gama-Castro, César Bonavides-Martínez, Carol Fulcher, Araceli M Huerta, Anamika Kothari, Markus Krummenacker and 14 more

Abstract read
In one paragraph

Article in Nucleic acids research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 314 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
314citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

314 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. CD177Cellular and molecular life sciences : CMLS · 2026
    Article
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  15. σeLife · 2023
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  20. FeFood chemistry. Molecular sciences · 2022
    Article

254 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Ingrid M KeselerSRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA. keseler@ai.sri.com
Amanda Mackie
Martin Peralta-Gil
Alberto Santos-Zavaleta
Socorro Gama-Castro
César Bonavides-Martínez
Carol Fulcher
Araceli M Huerta
Anamika Kothari
Markus Krummenacker
Mario Latendresse
Luis Muñiz-Rascado
Quang Ong
Suzanne Paley
Imke Schröder
Alexander G Shearer
Pallavi Subhraveti
Mike Travers
Deepika Weerasinghe
Verena Weiss
Julio Collado-Vides
Robert P Gunsalus
Ian Paulsen
Peter D Karp

Funding

The EcoCyc Model Organism Database for Escherichia coli [SRI Proposal ECU 14-631]U24GM077678 · NIGMS · SRI INTERNATIONAL · PI KARP, PETER D · 2006 to 2018
$12.3M
EcoliHub2.0: A next-generation E. coli model organism resource (SRI Proposal ECU U24GM088849 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HU, JAMES C, SHERLOCK, GAVIN J · 2009 to 2012
$4.4M
Gene Regulation: E.coli Database Integrated ModelingR01GM071962 · NIGMS · CENTER FOR GENOMIC SCIENCES · PI COLLADO-VIDES, JULIO · 2004 to 2011
$2.4M
NIGMS NIH HHS GM071962NIGMS NIH HHS GM088849NIGMS NIH HHS R01 GM071962NIGMS NIH HHS U24 GM077678NIGMS NIH HHS U24GM077678
6 · The paper itself

Abstract

EcoCyc (http://EcoCyc.org) is a model organism database built on the genome sequence of Escherichia coli K-12 MG1655. Expert manual curation of the functions of individual E. coli gene products in EcoCyc has been based on information found in the experimental literature for E. coli K-12-derived strains. Updates to EcoCyc content continue to improve the comprehensive picture of E. coli biology. The utility of EcoCyc is enhanced by new tools available on the EcoCyc web site, and the development of EcoCyc as a teaching tool is increasing the impact of the knowledge collected in EcoCyc.

Indexed as

Databases, GeneticBinding SitesEscherichia coli K12Escherichia coli ProteinsGene Expression Regulation, BacterialInternetMembrane Transport ProteinsModels, GeneticMolecular Sequence AnnotationPhenotypePosition-Specific Scoring MatricesPromoter Regions, GeneticSystems BiologyTranscription FactorsTranscription, GeneticEscherichia coli ProteinsMembrane Transport ProteinsTranscription Factors

Identifiers

PMID23143106
PMCPMC3531154

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.