ArticleNature structural & molecular biology2012
Structure of the vacuolar-type ATPase from Saccharomyces cerevisiae at 11-Å resolution.
Article in Nature structural & molecular biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 90 citations in OpenAlex.
- A heterotrimeric protein complex assembles the metazoan V-ATPase upon dissipation of proton gradients.Nature structural & molecular biology · 2025Article
- Eukaryotic yeast VFrontiers in molecular biosciences · 2024Article
- Chimeric a-subunit isoforms generate functional yeast V-ATPases with altered regulatory properties in vitro and in vivo.Molecular biology of the cell · 2023Article
- Structural basis of V-ATPase VProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Structural and functional understanding of disease-associated mutations in V-ATPase subunit a1 and other isoforms.Frontiers in molecular neuroscience · 2023Review
- Ras-mutant cancers are sensitive to small molecule inhibition of V-type ATPases in mice.Nature biotechnology · 2022Article
- The V-ATPases in cancer and cell death.Cancer gene therapy · 2022Review
- Coordinated conformational changes in the VNature structural & molecular biology · 2022Article
- Detection and quantification of the vacuolar H+ATPase using the Legionella effector protein SidK.The Journal of cell biology · 2022Article
- Toosendanin, a novel potent vacuolar-type HInternational journal of biological sciences · 2022Article
- CryoEM Reveals the Complexity and Diversity of ATP Synthases.Frontiers in microbiology · 2022Review
- Structure of Ycf1p reveals the transmembrane domain TMD0 and the regulatory region of ABCC transporters.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Electron cryomicroscopy observation of acyl carrier protein translocation in type I fungal fatty acid synthase.Scientific reports · 2019Article
- A pH-sensitive luminal His-cluster promotes interaction of PAM with V-ATPase along the secretory and endocytic pathways of peptidergic cells.Journal of cellular physiology · 2019Article
- Structural comparison of the vacuolar and Golgi V-ATPases fromProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Structural Asymmetry and Kinetic Limping of Single Rotary F-ATP Synthases.Molecules (Basel, Switzerland) · 2019Review
- A cation-π interaction in a transmembrane helix of vacuolar ATPase retains the proton-transporting arginine in a hydrophobic environment.The Journal of biological chemistry · 2018Article
- The Peripheral Stalk of Rotary ATPases.Frontiers in physiology · 2018Review
- Atomic model for the dimeric FScience (New York, N.Y.) · 2017Article
- Chemical screening identifies ATM as a target for alleviating senescence.Nature chemical biology · 2017Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Vacuolar-type ATPases (V-type ATPases) in eukaryotic cells are large membrane protein complexes that acidify various intracellular compartments. The enzymes are regulated by dissociation of the V(1) and V(O) regions of the complex. Here we present the structure of the Saccharomyces cerevisiae V-type ATPase at 11-Å resolution by cryo-EM of protein particles in ice. The structure explains many cross-linking and protein interaction studies. Docking of crystal structures suggests that inhibition of ATPase activity by the dissociated V(1) region involves rearrangement of the N- and C-terminal domains of subunit H and also suggests how this inhibition is triggered upon dissociation. We provide support for this model by demonstrating that mutation of subunit H to increase the rigidity of the linker between its two domains decreases its ability to inhibit ATPase activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.