ArticleInternational journal of legal medicine2013
Accuracy of targeted post-mortem computed tomography coronary angiography compared to assessment of serial histological sections.
Article in International journal of legal medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Postmortem CT angiography of fetuses, infants and children up to 12 years old a systematic review and conceptual decision tree.International journal of legal medicine · 2025Pooled it
- Postmortem computed tomography angiography (PMCTA) and traditional autopsy in cases of sudden cardiac death due to coronary artery disease: a systematic review and meta-analysis.La Radiologia medica · 2019Pooled it
- Histological artifacts induced by the contrast agent in Multi-Phase Post-Mortem CT Angiography (MPMCTA): Part I - Normal Tissues.Forensic science, medicine, and pathology · 2026Article
- Histological artifacts induced by the contrast agent in multi-phase post-mortem CT angiography (MPMCTA): Part II - Pathological tissues.Forensic science, medicine, and pathology · 2026Article
- Post-mortem ultrasound study of coronary circulation on ex-situ hearts.International journal of legal medicine · 2026Article
- The current state of forensic imaging - post mortem imaging.International journal of legal medicine · 2025Review
- Fatal coronary perforation during percutaneous coronary intervention: The medico-legal interest in establishing the correlation between in vivo imaging and post-mortem histopathology.Forensic science, medicine, and pathology · 2024Article
- High-risk coronary plaque of sudden cardiac death victims: postmortem CT angiographic features and histopathologic findings.International journal of legal medicine · 2024Article
- The value of PMCTA in the diagnosis of coronary atherosclerosis in isolated human hearts.Forensic sciences research · 2023Article
- Bleeding-Source Exploration in Subdural Hematoma: Observational Study on the Usefulness of Postmortem Computed Tomography Angiography.Diagnostics (Basel, Switzerland) · 2023Article
- Application of postmortem imaging modalities in cases of sudden death due to cardiovascular diseases-current achievements and limitations from a pathology perspective : Endorsed by the Association for European Cardiovascular Pathology and by the International Society of Forensic Radiology and Imaging.Virchows Archiv : an international journal of pathology · 2023Article
- State of the Art on the Role ofTomography (Ann Arbor, Mich.) · 2022Review
- Impact of increasing levels of adaptive statistical iterative reconstruction on image quality in oil-based postmortem CT angiography in coronary arteries.International journal of legal medicine · 2021Article
- Oleic Acid (OA), A Potential Dual Contrast Agent for Postmortem MR Angiography (PMMRA): A Pilot Study.Current medical science · 2020Article
- Diagnosis of myocardial infarction at autopsy: AECVP reappraisal in the light of the current clinical classification.Virchows Archiv : an international journal of pathology · 2020Review
- Postmortem imaging as a complementary tool for the investigation of cardiac death.Forensic sciences research · 2019Review
- Article
- Forensic Radiology: An Update.Journal of the Belgian Society of Radiology · 2017Article
- Diagnostic accuracy of post-mortem CT with targeted coronary angiography versus autopsy for coroner-requested post-mortem investigations: a prospective, masked, comparison study.Lancet (London, England) · 2017Article
- Post-mortem computed tomography angiography using left ventricle cardiac puncture: A whole-body, angiographic approach.PloS one · 2017Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Post-mortem computed tomography with coronary angiography (PMCTA) could have a role in the investigation of sudden natural death. This study assesses the accuracy of targeted coronary PMCTA, using both air and iodinated contrast media, to provide sensitivity and specificity for critical stenosis (CS) on a segmental basis, based on a gold standard of 3-5 mm serial sections of the coronary arteries using macroscopic and histological techniques. Assessment of stenosis at 1 mm intervals on PMCTA was compared with the data from pathological analysis. Stenosis was defined as "critical" when the stenotic region reaches ≥75 %. Regions were defined every 20 mm or by a clear change in stenosis. Discrepancies were defined as significant if only one test showed CS. Five cases with 25 vessels with 124 regions were assessed. PMCTA was unable to identify plaque hemorrhage or dissection (but this was normally associated with CS). Eighteen segments had significant discrepancies, giving a sensitivity and specificity of 50 and 91.5 %. When an alternative gold standard was constructed by excluding regions beyond a CS (five cases), taking PMCTA as correct where a heavily calcified vessel opens under contrast injection (four cases), and correcting for misregistration of distance (one case), the sensitivity rose to 85.7 %. There was complete agreement when the right or left coronary arteries are assessed as a whole. This study shows that PMCTA is not a perfect replacement for histological examination of coronary vessels, but may have a role in routine post-mortem investigation.
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Registered trials
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