ArticleExperimental hematology2013
SOD2 deficiency in hematopoietic cells in mice results in reduced red blood cell deformability and increased heme degradation.
Article in Experimental hematology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Article
- Hypermethylation of BMPR2 and TGF-β Promoter Regions in Tibetan Patients with High-Altitude Polycythemia at Extreme Altitude.Biochemical genetics · 2025Article
- Article
- A system-level model reveals that transcriptional stochasticity is required for hematopoietic stem cell differentiation.NPJ systems biology and applications · 2024Article
- Decoding functional hematopoietic progenitor cells in the adult human lung.Research square · 2024Article
- Analysis of SOD2 rs4880 Genetic Variant in Patients with Alzheimer's Disease.Current issues in molecular biology · 2022Article
- The Effect of Low-Energy Laser-Driven Ultrashort Pulsed Electron Beam Irradiation on Erythropoiesis and Oxidative Stress in Rats.International journal of molecular sciences · 2022Article
- Association of Genetic Variants inGenes · 2022Article
- Impact of Superoxide Dismutase Genetic Polymorphism (SOD2 Val16Ala) and Superoxide Dismutase Level on Disease Severity in a Cohort of Egyptian Sickle Cell Disease Patients.Mediterranean journal of hematology and infectious diseases · 2022Article
- Decrease in membrane fluidity and traction force induced by silica-coated magnetic nanoparticles.Journal of nanobiotechnology · 2021Article
- Changes in the Activity and Concentration of Superoxide Dismutase Isoenzymes (Cu/Zn SOD, MnSOD) in the Blood of Healthy Subjects and Patients with Acute Pancreatitis.Antioxidants (Basel, Switzerland) · 2020Article
- Hematopoietic Stem Cell Metabolism during Development and Aging.Developmental cell · 2020Review
- Decoding the role of SOD2 in sickle cell disease.Blood advances · 2019Review
- Role of Peroxiredoxin 2 in the Protection Against Ferrous Sulfate-Induced Oxidative and Inflammatory Injury in PC12 Cells.Cellular and molecular neurobiology · 2018Article
- The effect of xanthine oxidase and hypoxanthine on the permeability of red cells from patients with sickle cell anemia.Physiological reports · 2018Article
- Red cell distribution width and renal outcome in patients with non-dialysis-dependent chronic kidney disease.PloS one · 2018Observational
- Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia.Antioxidants & redox signaling · 2017Review
- Toxicogenomics of Phenylhydrazine Induced Hematotoxicity and its Attenuation by Plumbagin from Plumbago zeylanica.Pharmacognosy magazine · 2015Article
- Oxidative stress as a potential causal factor for autoimmune hemolytic anemia and systemic lupus erythematosus.World journal of nephrology · 2015Review
- Impaired erythrocyte deformability in transgenic HO-1G143H mutant mice.Transgenic research · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Among the three types of super oxide dismutases (SODs) known, SOD2 deficiency is lethal in neonatal mice owing to cardiomyopathy caused by severe oxidative damage. SOD2 is found in red blood cell (RBC) precursors, but not in mature RBCs. To investigate the potential damage to mature RBCs resulting from SOD2 deficiency in precursor cells, we studied RBCs from mice in which fetal liver stem cells deficient in SOD2 were capable of efficiently rescuing lethally irradiated host animals. These transplanted animals lack SOD2 only in hematopoietically generated cells and live longer than SOD2 knockouts. In these mice, approximately 2.8% of their total RBCs in circulation are iron-laden reticulocytes, with numerous siderocytic granules and increased protein oxidation similar to that seen in sideroblastic anemia. We have studied the RBC deformability and oxidative stress in these animals and the control group by measuring them with a microfluidic ektacytometer and assaying fluorescent heme degradation products with a fluorimeter, respectively. In addition, the rate of hemoglobin oxidation in RBCs from these mice and the control group were measured spectrophotometrically. The results show that RBCs from these SOD2-deficient mice have reduced deformability, increased heme degradation products, and an increased rate of hemoglobin oxidation compared with control animals, indicative of increased RBC oxidative stress.
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