ArticleAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2013
Urine arsenic and prevalent albuminuria: evidence from a population-based study.
Article in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 81 citations in OpenAlex.
- Effect of an Arsenic Mitigation Program on Arsenic Exposure in American Indian Communities: A Cluster Randomized Controlled Trial of the Community-Led Strong Heart Water Study Program.Environmental health perspectives · 2024Trial
- Behavioral determinants of arsenic-safe water use among Great Plains Indian Nation private well users: results from the Community-Led Strong Heart Water Study Arsenic Mitigation Program.Environmental health : a global access science source · 2023Trial
- Evaluation of a water arsenic filter in a participatory intervention to reduce arsenic exposure in American Indian communities: The Strong Heart Water Study.The Science of the total environment · 2023Trial
- Evaluation of Ambient Air Particulate Matter, Urine Arsenic Levels and the Effect on Residents Health in an Artisanal Mining Community and an Incorporated Mining Community in Ghana From April 2024 to July 2024: A Cross-Sectional Study.Health science reports · 2026Article
- Arsenic species and lipid metabolism under low-to-moderate arsenic exposure: evidence from NHANES and a Chinese adult population.Frontiers in endocrinology · 2026Article
- Longitudinal leucocyte DNA methylation changes in Mesoamerican nephropathy.Environmental epigenetics · 2025Article
- Biomonitoring of inorganic arsenic species in pregnancy.Journal of exposure science & environmental epidemiology · 2023Review
- C/EBPβ-TFAM-Mediated NLRP3 Inflammasome Activation Contributes to Arsenic-Induced Rat Kidney Injury.Toxics · 2023Article
- Environmental metal exposures and kidney function of Guatemalan sugarcane workers.Journal of exposure science & environmental epidemiology · 2022Article
- The association of arsenic exposure and arsenic metabolism with all-cause, cardiovascular and cancer mortality in the Strong Heart Study.Environment international · 2022Article
- Spatial relationship between well water arsenic and uranium in Northern Plains native lands.Environmental pollution (Barking, Essex : 1987) · 2021Article
- Article
- A Review of Metal Exposure Studies Conducted in the Rural Southwestern and Mountain West Region of the United States.Current epidemiology reports · 2019Article
- Risk factors for chronic kidney disease of non-traditional causes: a systematic review.Revista panamericana de salud publica = Pan American journal of public health · 2019Review
- A Review of Environmental Epidemiology Studies in Southwestern and Mountain West Rural Minority Populations.Current epidemiology reports · 2018Article
- Low-level inorganic arsenic exposure and neuropsychological functioning in American Indian elders.Environmental research · 2017Article
- Human exposure to dietary inorganic arsenic and other arsenic species: State of knowledge, gaps and uncertainties.The Science of the total environment · 2017Article
- Low-moderate urine arsenic and biomarkers of thrombosis and inflammation in the Strong Heart Study.PloS one · 2017Article
- 2,3,5,6-Tetramethylpyrazine (TMP) down-regulated arsenic-induced heme oxygenase-1 and ARS2 expression by inhibiting Nrf2, NF-κB, AP-1 and MAPK pathways in human proximal tubular cells.Archives of toxicology · 2016Article
- Metal mixtures in urban and rural populations in the US: The Multi-Ethnic Study of Atherosclerosis and the Strong Heart Study.Environmental research · 2016Article
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11 authors at 6 institutions in 3 countries.
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Abstract
backgroundLong-term arsenic exposure is a major global health problem. However, few epidemiologic studies have evaluated the association of arsenic with kidney measures. Our objective was to evaluate the cross-sectional association between inorganic arsenic exposure and albuminuria in American Indian adults from rural areas of Arizona, Oklahoma, and North and South Dakota. STUDY
designCross-sectional. SETTING & PARTIPANTS: Strong Heart Study locations in Arizona, Oklahoma, and North and South Dakota. 3,821 American Indian men and women aged 45-74 years with urine arsenic and albumin measurements. PREDICTOR: Urine arsenic. OUTCOMES: Urine albumin-creatinine ratio and albuminuria status. MEASUREMENTS: Arsenic exposure was estimated by measuring total urine arsenic and urine arsenic species using inductively coupled plasma mass spectrometry (ICPMS) and high-performance liquid chromatography-ICPMS, respectively. Urine albumin was measured by automated nephelometric immunochemistry.
resultsThe prevalence of albuminuria (albumin-creatinine ratio ≥30 mg/g) was 30%. Median value for the sum of inorganic and methylated arsenic species was 9.7 (IQR, 5.8-15.6) μg per gram of creatinine. Multivariable-adjusted prevalence ratios of albuminuria (albumin-creatinine ratio ≥30 mg/g) comparing the 3 highest to lowest quartiles of the sum of inorganic and methylated arsenic species were 1.16 (95% CI, 1.00-1.34), 1.24 (95% CI, 1.07-1.43), and 1.55 (95% CI, 1.35-1.78), respectively (P for trend <0.001). The association between urine arsenic and albuminuria was observed across all participant subgroups evaluated and was evident for both micro- and macroalbuminuria. LIMITATIONS: The cross-sectional design cannot rule out reverse causation.
conclusionsIncreasing urine arsenic concentrations were cross-sectionally associated with increased albuminuria in a rural US population with a high burden of diabetes and obesity. Prospective epidemiologic and mechanistic evidence is needed to understand the role of arsenic as a kidney disease risk factor.
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