ArticleJournal of neuroscience methods2013
Three variations in rabbit angiographic stroke models.
Article in Journal of neuroscience methods, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Inhibition of proprotein convertase SKI-1 prevents blood vessel alteration after stroke.Nature cardiovascular research · 2025Article
- Constructing a Transient Ischemia Attack Model Utilizing Flexible Spatial Targeting Photothrombosis with Real-Time Blood Flow Imaging Feedback.International journal of molecular sciences · 2024Article
- Modeling transient ischemic attack via photothrombosis.Biophysical reviews · 2023Review
- Increasing miR-126 Can Prevent Brain Injury after Intracerebral Hemorrhage in Rats by Regulating ZEB1.Contrast media & molecular imaging · 2022Article
- Longitudinal effects of common carotid artery stenosis on ocular hemodynamics assessed using laser speckle flowgraphy in a rabbit model.Scientific reports · 2020Article
- Animal models of transient ischemic attack: a review.Acta neurologica Belgica · 2020Review
- Dynamic EPR Oximetry of Changes in Intracerebral Oxygen Tension During Induced Thromboembolism.Cell biochemistry and biophysics · 2017Article
- Dodecafluoropentane Improves Neurological Function Following Anterior Ischemic Stroke.Molecular neurobiology · 2017Article
- MicroRNA367 negatively regulates the inflammatory response of microglia by targeting IRAK4 in intracerebral hemorrhage.Journal of neuroinflammation · 2015Article
- Dodecafluoropentane Emulsion Extends Window for tPA Therapy in a Rabbit Stroke Model.Molecular neurobiology · 2015Article
- Progress in dodecafluoropentane emulsion as a neuroprotective agent in a rabbit stroke model.Molecular neurobiology · 2013Article
- Neurological assessment scores in rabbit embolic stroke models.The open neurology journal · 2013Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo develop angiographic models of embolic stroke in the rabbit using pre-formed clot or microspheres to model clinical situations ranging from transient ischemic events to severe ischemic stroke. MATERIALS AND
methodsNew Zealand White rabbits (N=151) received angiographic access to the internal carotid artery (ICA) from a femoral approach. Variations of emboli type and quantity of emboli were tested by injection into the ICA. These included fresh clots (1.0-mm length, 3-6h), larger aged clots (4.0-mm length, 3 days), and 2 or 3 insoluble microspheres (700-900 μm). Neurological assessment scores (NAS) were based on motor, sensory, balance, and reflex measures. Rabbits were euthanized at 4, 7, or 24h after embolization, and infarct volume was measured as a percent of total brain volume using 2,3,5-triphenyltetrazolium chloride (TTC).
resultsInfarct volume percent at 24 h after stroke was lower for rabbits embolized with fresh clot (0.45±0.14%), compared with aged clot (3.52±1.31%) and insoluble microspheres (3.39±1.04%). Overall NAS (including posterior vessel occlusions) were positively correlated to infarct volume percent measurements in the fresh clot (r=0.50), aged clot (r=0.65) and microsphere (r=0.62) models (p<0.001).
conclusionThe three basic angiographic stroke models may be similar to human transient ischemic attacks (TIA) (fresh clot), major strokes that can be thrombolysed (aged clot), or major strokes with insoluble emboli such as atheromata (microspheres). Model selection can be tailored to specific research needs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.