Evidence map›Paper›PMID 23141188›Full record

SynthesisThe journal of pain2012

A meta-analytic review of the hypoalgesic effects of exercise.

Kelly M Naugle, Roger B Fillingim, Joseph L Riley

4 registry-linked trialsOpen access · bronzeAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The journal of pain, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 206 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
206citing papers in PubMed, 16 pooled it
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03675399 nacompletednot on this mapstarted 2019, after this paper: background citation

Effect of Isometric Exercise on Pain Perception in Subjects With Rotator Cuff Related Shoulder Pain

TypeinterventionalSponsorUniversity of ValenciaRan2019 to 2021Enrolled35ConditionsRotator Cuff TendinitisArmsSupra-threshold isometric exercise, Infra-threshold isometric exercise
NCT04902196 nacompletednot on this mapstarted 2021, after this paper: background citation

Acute Effects of a High Intensity Training Protocol on Pain Processing and Inflammatory Parameters in Persons With Chronic Nonspecific Low Back Pain.

TypeinterventionalSponsorHasselt UniversityRan2021 to 2022Enrolled40ConditionsLow Back Pain, InflammationArmshigh intensity cardiorespiratory exercise protocol, moderate intensity cardiorespiratory exercise protocol
NCT05613998 nacompletednot on this mapstarted 2022, after this paper: background citation

Global Postural Reeducation vs. Non-specific Therapeutic Exercise in the Treatment of Rotator Cuff Tendinopathies of the Shoulder

TypeinterventionalSponsorUniversidad Francisco de VitoriaRan2022 to 2025Enrolled66ConditionsRotator Cuff TendinosisArmsGPR Group, Aerobic Exercice Group
NCT06295276 nacompletednot on this mapstarted 2024, after this paper: background citation

Does a Teletherapy-guided Exercise Programme Improve Pain Intensity, Disability, and Quality of Life in Nursing Students With Back and Neck Pain Compared to a Control Group?

TypeinterventionalSponsorHochschule OsnabruckRan2024 to 2024Enrolled48ConditionsLow Back Pain, Neck PainArmsteletherapy-guided exercise programme, Waiting list/control intervention/delayed teletherapy intervention
3 · Its place in the literature

Who cites it

206 citing papers in PubMed, 16 syntheses or guidelines pooled it, 598 citations in OpenAlex.

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146 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Kelly M NauglePain Research and Intervention Center for Excellence, University of Florida, Gainesville, FL, USA. knaugle@dentalufl.edu
Roger B Fillingim
Joseph L Riley
University of Florida · US

Funding

University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI CHRISTIAAN LEEUWENBURGH · 2007 to 2026
$22.8M
Integrative and translational training in pain researchT32NS045551 · NINDS · UNIVERSITY OF FLORIDA · PI YEZIERSKI, ROBERT P. · 2005 to 2014
$1.8M
NIA NIH HHS P30 AG028740NINDS NIH HHS T32 NS045551NINDS NIH HHS T32NS045551-06
6 · The paper itself

Abstract

unlabelledThe purpose of this article was to examine the effects of acute exercise on pain perception in healthy adults and adults with chronic pain using meta-analytic techniques. Specifically, studies using a repeated measures design to examine the effect of acute isometric, aerobic, or dynamic resistance exercise on pain threshold and pain intensity measures were included in this meta-analysis. The results suggest that all 3 types of exercise reduce perception of experimentally induced pain in healthy participants, with effects ranging from small to large depending on pain induction method and exercise protocol. In healthy participants, the mean effect size for aerobic exercise was moderate (d(thr) = .41, d(int) = .59), while the mean effect sizes for isometric exercise (d(thr) = 1.02, d(int) = .72) and dynamic resistance exercise (d(thr) = .83, d(int) = .75) were large. In chronic pain populations, the magnitude and direction of the effect sizes were highly variable for aerobic and isometric exercise and appeared to depend on the chronic pain condition being studied as well as the intensity of the exercise. While trends could be identified, the optimal dose of exercise that is needed to produce hypoalgesia could not be systematically determined with the amount of data available. PERSPECTIVE: This article presents a quantitative review of the exercise-induced hypoalgesia literature. This review raises several important questions that need to be addressed while also demonstrating that acute exercise has a hypoalgesic effect on experimentally induced pain in healthy adults, and both a hypoalgesic and hyperalgesic effect in adults with chronic pain.

Indexed as

PainExerciseHumansPain ManagementPain MeasurementPain Threshold

Identifiers

PMID23141188
PMCPMC3578581
OpenAlexW2031307230

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.