ArticleNeuron2012
High-resolution fMRI reveals laminar differences in neurovascular coupling between positive and negative BOLD responses.
Article in Neuron, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 138 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
138 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Translation of task-evoked negative BOLD response into aging and Alzheimer's disease: a systematic review of the current literature.Journal of translational medicine · 2025Pooled it
- Neurochemical underpinning of hemodynamic response to neuropsychiatric drugs: A meta- and cluster analysis of preclinical studies.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Pooled it
- Metabolite concentration changes associated with positive and negative BOLD responses in the human visual cortex: A functional MRS study at 7 Tesla.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Trial
- Laminar activity in the hippocampus and entorhinal cortex related to novelty and episodic encoding.Nature communications · 2014Trial
- Negative BOLD response to interictal discharges in epilepsy using intracranial EEG-fMRI.Neuroimage. Reports · 2026Article
- Characterising the Diffusion Functional Signature of Negative BOLD With Interleaved TMS-fMRI in the Human Brain.Human brain mapping · 2026Article
- The neurovascular coupling basis of cognitive impairment in patients with H-type hypertension: a cross-modal study using resting-state fMRI and arterial spin labeling.Frontiers in medicine · 2026Article
- Cross-regional real-time visualization of systemic physiology and dynamics with 3D panoramic photoacoustic computed tomography (3D-PanoPACT).Nature communications · 2025Article
- Article
- Decoding paradoxical BOLD responses to transcranial ultrasound stimulation with concurrent optoacoustic magnetic resonance imaging.Science advances · 2025Article
- Type-I nNOS neurons orchestrate cortical neural activity and vasomotion.bioRxiv : the preprint server for biology · 2025Article
- Machine Learning-Based Clustering of Layer-Resolved fMRI Activation and Functional Connectivity Within the Primary Somatosensory Cortex in Nonhuman Primates.Human brain mapping · 2025Article
- Revealing layer-specific cortical activity in human M1 using high-resolution line-scanning fMRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Unresponsiveness induced by sevoflurane and propofol is associated with reduced basal forebrain cholinergic nuclei functional connectivity in humans,Neuroimage. Reports · 2024Article
- Laminar multi-contrast fMRI at 7T allows differentiation of neuronal excitation and inhibition underlying positive and negative BOLD responses.medRxiv : the preprint server for health sciences · 2024Article
- High Spatiotemporal Resolution Radial Encoding Single-Vessel fMRI.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Rat superior colliculus encodes the transition between static and dynamic vision modes.Nature communications · 2024Article
- Laminar multi-contrast fMRI at 7T allows differentiation of neuronal excitation and inhibition underlying positive and negative BOLD responses.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Whole-brain responses to visual and auditory stimuli in anesthetized and minimally restrained awake mice using quiet zero echo time fMRI.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Similar somatotopy for active and passive digit representation in primary somatosensory cortex.Human brain mapping · 2023Article
78 more citing papers are in PubMed but not listed here.
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Funding
Abstract
The six cortical layers have distinct anatomical and physiological properties, like different energy use and different feedforward and feedback connectivity. It is not known if and how layer-specific neural processes are reflected in the fMRI signal. To address this question we used high-resolution fMRI to measure BOLD, CBV, and CBF responses to stimuli that elicit positive and negative BOLD signals in macaque primary visual cortex. We found that regions with positive BOLD responses had parallel increases in CBV and CBF, whereas areas with negative BOLD responses showed a decrease in CBF but an increase in CBV. For positive BOLD responses, CBF and CBV increased in the center of the cortex, but for negative BOLD responses, CBF decreased superficially while CBV increased in the center. Our findings suggest different mechanisms for neurovascular coupling for BOLD increases and decreases, as well as laminar differences in neurovascular coupling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.