ArticleNeuron2012
Visual stimulation reverses the directional preference of direction-selective retinal ganglion cells.
Article in Neuron, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 62 citations in OpenAlex.
- Rod photoreceptors control the ON vs OFF polarity of cone-signaling neurons.Communications biology · 2026Article
- Virtual reality stimulation for neuroprotection and neuroenhancement of vision in optic neuropathy patients: a prospective clinical trial.BMC ophthalmology · 2025Article
- Retina-derived signals control pace of neurogenesis in visual brain areas but not circuit assembly.Nature communications · 2023Article
- Long-timescale anti-directional rotation ineLife · 2023Article
- Asymmetric connections with starburst amacrine cells underlie the upward motion selectivity of J-type retinal ganglion cells.PLoS biology · 2023Article
- Long timescale anti-directional rotation in Drosophila optomotor behavior.bioRxiv : the preprint server for biology · 2023Article
- ON and OFF Signaling Pathways in the Retina and the Visual System.Frontiers in ophthalmology · 2022Article
- Dissecting cascade computational components in spiking neural networks.PLoS computational biology · 2021Article
- Functional-pathway-dominant contrast adaptation and sensitization in mouse retinal ganglion cells.Cognitive neurodynamics · 2020Article
- Intraocular Pressure Elevation Compromises Retinal Ganglion Cell Light Adaptation.Investigative ophthalmology & visual science · 2020Article
- Early Visual Motion Experience Improves Retinal Encoding of Motion Directions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Visual Experience Influences Dendritic Orientation but Is Not Required for Asymmetric Wiring of the Retinal Direction Selective Circuit.Cell reports · 2020Article
- Article
- Dendritic Spikes Expand the Range of Well Tolerated Population Noise Structures.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Retinal direction selectivity in the absence of asymmetric starburst amacrine cell responses.eLife · 2019Article
- Pathway-Specific Asymmetries between ON and OFF Visual Signals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Stimulus-dependent engagement of neural mechanisms for reliable motion detection in the mouse retina.Journal of neurophysiology · 2018Review
- Inferring circuit mechanisms from sparse neural recording and global perturbation in grid cells.eLife · 2018Article
- Flexible Neural Hardware Supports Dynamic Computations in Retina.Trends in neurosciences · 2018Review
- Functional Compartmentalization within Starburst Amacrine Cell Dendrites in the Retina.Cell reports · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Direction selectivity in the retina is mediated by direction-selective ganglion cells. These cells are part of a circuit in which they are asymmetrically wired to inhibitory neurons. Thus, they respond strongly to an image moving in the preferred direction and weakly to an image moving in the opposite (null) direction. Here, we demonstrate that adaptation with short visual stimulation of a direction-selective ganglion cell using drifting gratings can reverse this cell's directional preference by 180°. This reversal is robust, long lasting, and independent of the animal's age. Our findings indicate that, even within circuits that are hardwired, the computation of direction can be altered by dynamic circuit mechanisms that are guided by visual stimulation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.