Trial reportDental materials : official publication of the Academy of Dental Materials2013
Novel calcium phosphate nanocomposite with caries-inhibition in a human in situ model.
Trial report in Dental materials : official publication of the Academy of Dental Materials, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it, 159 citations in OpenAlex.
- Secondary Caries in situ Models: A Systematic Review.Caries research · 2018Pooled it
- Review
- Surface wear and roughness of experimental composites containing calcium orthophosphate particles following toothbrush abrasion.European journal of oral sciences · 2026Article
- Evaluation of Mechanical and Elemental Properties of Bioceramic-Coated Orthodontic Brackets and Enamel Surface.European journal of dentistry · 2025Article
- Antimicrobial, remineralization, and infiltration: advanced strategies for interrupting dental caries.Medical review (2021) · 2025Review
- One year monitoring of calcium release from an experimental composite containing calcium phosphate particles.Biomaterial investigations in dentistry · 2025Article
- Compositional boundaries for functional dental composites containing calcium orthophosphate particles.Journal of the mechanical behavior of biomedical materials · 2023Article
- Inorganic Compounds as Remineralizing Fillers in Dental Restorative Materials: Narrative Review.International journal of molecular sciences · 2023Review
- TEGDMA-Functionalized Dicalcium Phosphate Dihydrate Resin-Based Composites Prevent Secondary Caries in an In Vitro Biofilm Model.Journal of functional biomaterials · 2022Article
- Bionanocomposites in Caries Prevention and Treatment: A Systematic Review.Journal of pharmacy & bioallied sciences · 2022Review
- Dentin remineralization in acidic solution without initial calcium phosphate ions via poly(amido amine) and calcium phosphate nanocomposites after fluid challenges.Clinical oral investigations · 2022Article
- Novel calcium phosphate ion-rechargeable and antibacterial adhesive to inhibit dental caries.Clinical oral investigations · 2022Article
- Antimicrobial potential of resin matrices loaded with coffee compounds.Journal of biomedical materials research. Part B, Applied biomaterials · 2021Article
- Novel Crown Cement Containing Antibacterial Monomer and Calcium Phosphate Nanoparticles.Nanomaterials (Basel, Switzerland) · 2020Article
- Novel Nanocomposite Inhibiting Caries at the Enamel Restoration Margins in an In Vitro Saliva-Derived Biofilm Secondary Caries Model.International journal of molecular sciences · 2020Article
- Use of nanoparticles in skeletal tissue regeneration and engineering.Histology and histopathology · 2020Review
- Cerium Dioxide Particles to Tune Radiopacity of Dental Adhesives: Microstructural and Physico-Chemical Evaluation.Journal of functional biomaterials · 2020Article
- Ion release and recharge from a fissure sealant containing amorphous calcium phosphate.PloS one · 2020Article
- Organic-Mineral Interaction between Biomimetic Materials and Hard Dental Tissues.Sovremennye tekhnologii v meditsine · 2020Article
- Effects ofRSC advances · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesSecondary caries at the restoration margins remains the main reason for failure. Although calcium phosphate (CaP) composites are promising for caries inhibition, there has been no report of CaP composite to inhibit caries in situ. The objectives of this study were to investigate the caries-inhibition effect of nanocomposite containing nanoparticles of amorphous calcium phosphate (NACP) in a human in situ model for the first time, and to determine colony-forming units (CFU) and Ca and P ion concentrations of biofilms on the composite restorations.
methodsNACP with a mean particle size of 116 nm were synthesized via a spray-drying technique. Two composites were fabricated: NACP nanocomposite, and control composite filled with glass particles. Twenty-five volunteers wore palatal devices containing bovine enamel slabs with cavities restored with NACP or control composite. After 14 days, the adherent biofilms were collected for analyses. Transverse microradiography determined the enamel mineral profiles at the margins, and the enamel mineral loss ΔZ was measured.
resultsNACP nanocomposite released Ca and P ions and the release significantly increased at cariogenic low pH (p<0.05). Biofilms on NACP nanocomposite contained higher Ca (p=0.007) and P ions (p=0.005) than those of control (n=25). There was no significant difference in biofilm CFU between the two composites (p>0.1). Microradiographs showed typical subsurface lesions in enamel next to control composite, but much less lesion around NACP nanocomposite. Enamel mineral loss ΔZ (mean±sd; n=25) around NACP nanocomposite was 13.8±9.3 μm, much less than 33.5±19.0 μm of the control (p=0.001). SIGNIFICANCE: Novel NACP nanocomposite substantially reduced caries formation in a human in situ model for the first time. Enamel mineral loss at the margins around NACP nanocomposite was less than half of the mineral loss around control composite. Therefore, the Ca and P ion-releasing NACP nanocomposite is promising for caries-inhibiting restorations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.