ArticleMicrocirculation (New York, N.Y. : 1994)2013
Vascular tone and Ca(2+) signaling in murine cremaster muscle arterioles in vivo.
Article in Microcirculation (New York, N.Y. : 1994), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 22 citations in OpenAlex.
- TRPV1 in arteries enables a rapid myogenic tone.The Journal of physiology · 2022Article
- Computer-assisted image analysis of agonist-mediated microvascular constriction response in mouse cremaster muscle.PloS one · 2022Article
- NO-induced vasodilation correlates directly with BP in smooth muscle-Na/Ca exchanger-1-engineered mice: elevated BP does not attenuate endothelial function.American journal of physiology. Heart and circulatory physiology · 2021Article
- Voltage-gated CaAmerican journal of physiology. Heart and circulatory physiology · 2018Article
- Imaging sympathetic neurogenic CaAutonomic neuroscience : basic & clinical · 2017Review
- Regional heterogeneity in the mechanisms of myogenic tone in hamster arterioles.American journal of physiology. Heart and circulatory physiology · 2017Article
- Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles.Comprehensive Physiology · 2017Review
- PC-PLC/sphingomyelin synthase activity plays a central role in the development of myogenic tone in murine resistance arteries.American journal of physiology. Heart and circulatory physiology · 2015Article
- Conditional knockout of smooth muscle sodium calcium exchanger type-1 lowers blood pressure and attenuates Angiotensin II-salt hypertension.Physiological reports · 2015Article
- A method for noninvasive longitudinal measurements of [Ca2+] in arterioles of hypertensive optical biosensor mice.American journal of physiology. Heart and circulatory physiology · 2014Article
- More in vivo experimentation is needed in cardiovascular physiology.American journal of physiology. Heart and circulatory physiology · 2014Article
- Ca(2+) signaling in arterioles and small arteries of conscious, restrained, optical biosensor mice.Frontiers in physiology · 2014Article
- Correlative intravital imaging of cGMP signals and vasodilation in mice.Frontiers in physiology · 2014Article
- Should we be sympathetic to angiotensin II infusion?The Journal of physiology · 2013Article
- Intravital Förster resonance energy transfer imaging reveals elevated [Ca2+]i and enhanced sympathetic tone in femoral arteries of angiotensin II-infused hypertensive biosensor mice.The Journal of physiology · 2013Article
- Smooth muscle cell Ca²⁺: think locally, act globally.Microcirculation (New York, N.Y. : 1994) · 2013Article
- Calcium dynamics in vascular smooth muscle.Microcirculation (New York, N.Y. : 1994) · 2013Review
- Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectivesWe sought to determine some of the molecular requirements for basal state "tone" of skeletal muscle arterioles in vivo, and whether asynchronous Ca(2+) waves are involved or not.
methodsCremaster muscles of anesthetized exMLCK and smGCaMP2 biosensor mice were exteriorized, and the fluorescent arterioles were visualized with wide-field, confocal or multiphoton microscopy to observe Ca(2+) signaling and arteriolar diameter.
resultsBasal state tone of the arterioles was ~50%. Local block of Ang-II receptors (AT1 ) or α1 -adrenoceptors (α1 -AR) had no effect on diameter, nor did complete block of sympathetic nerve activity (SNA). Inhibition of phospholipase C caused dilation nearly to the Ca(2+) -free (passive) diameter, as did exposure to nifedipine or 2-APB. Arterioles were also dilated when treated with SKF96365. High-resolution imaging of exMLCK fluorescence (ratio) or GCaMP2 fluorescence in smooth muscle cells failed to reveal Ca(2+) waves (although Ca(2+) waves/transients were readily detected by both biosensors in small arteries, ex vivo).
conclusionsArterioles of cremaster muscle have vascular tone of ~ 50%, which is not due to α1 -AR, AT1 R, or SNA. PLC activity, L-type Ca(2+) channels, 2-APB- and SKF96365-sensitive channels are required. Propagating Ca(2+) waves are not present. A key role for PLC and InsP3 R in vascular tone in vivo, other than producing Ca(2+) waves, is suggested.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.