ArticleCritical care (London, England)2012
Cell-free DNA and outcome in sepsis.
Article in Critical care (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- D-dimer corrected for thrombin and plasmin generation is a strong predictor of mortality in patients with sepsis.Blood transfusion = Trasfusione del sangue · 2020Trial
- The effect of therapeutic plasma exchange on the inflammatory response in septic shock: a secondary analysis of the EXCHANGE-1 trial.Intensive care medicine experimental · 2025Article
- Decoding Sepsis: Unraveling Key Signaling Pathways for Targeted Therapies.Research (Washington, D.C.) · 2025Review
- Review
- Extending the 'host response' paradigm from sepsis to cardiogenic shock: evidence, limitations and opportunities.Critical care (London, England) · 2023Review
- Heparin, Heparan Sulphate and Sepsis: Potential New Options for Treatment.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Clinical Characteristics of Severe COVID-19 Patients During Omicron Epidemic and a Nomogram Model Integrating Cell-Free DNA for Predicting Mortality: A Retrospective Analysis.Infection and drug resistance · 2023Article
- Single-step measurement of cell-free DNA for sepsis prognosis using a thread-based microfluidic device.Mikrochimica acta · 2022Article
- Review
- Signaling pathways and intervention therapies in sepsis.Signal transduction and targeted therapy · 2021Review
- Utility of cell-free DNA concentrations and illness severity scores to predict survival in critically ill neonatal foals.PloS one · 2021Article
- Sepsis 2019: What Surgeons Need to Know.Surgical infections · 2020Review
- Value of dynamic plasma cell-free DNA monitoring in septic shock syndrome: A case report.World journal of clinical cases · 2020Article
- Decreased integrity of exercise-induced plasma cell free nuclear DNA - negative association with the increased oxidants production by circulating phagocytes.Scientific reports · 2019Article
- Evaluating the discriminating capacity of cell death (apoptotic) biomarkers in sepsis.Journal of intensive care · 2018Article
- ALK is a therapeutic target for lethal sepsis.Science translational medicine · 2017Article
- Septic Shock and the Aging Process: A Molecular Comparison.Frontiers in immunology · 2017Article
- Dynamic pathology for circulating free DNA in a dextran sodium sulfate colitis mouse model.Pediatric surgery international · 2014Article
- Admission cell free DNA levels predict 28-day mortality in patients with severe sepsis in intensive care.PloS one · 2014Article
Corrections and comments
- Comment on
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Severe sepsis can be a catastrophic condition that is often associated with poor outcomes. The early diagnosis and management of the condition are vital in order to improve the chances of survival. However, owing to the syndromal nature of its definition and the lack of a biomarker able to accurately confirm the condition, the diagnosis of sepsis is challenging. Even more challenging is the prediction of how these patients will respond to the therapy and whether they will survive the intensive care and the hospital admission.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.