ArticleJournal of proteome research2012
Amino termini of many yeast proteins map to downstream start codons.
Article in Journal of proteome research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Supersaturation mutagenesis reveals adaptive rewiring of essential genes among malaria parasites.Science (New York, N.Y.) · 2025Article
- Alternative translation initiation by ribosomal leaky scanning produces multiple isoforms of the Pif1 helicase.Nucleic acids research · 2024Article
- Alternative Transcription Start Site Usage and Functional Implications in Pathogenic Fungi.Journal of fungi (Basel, Switzerland) · 2022Review
- Transcriptomic complexity of the human malaria parasite Plasmodium falciparum revealed by long-read sequencing.PloS one · 2022Article
- An Internal Promoter Drives the Expression of a Truncated Form ofMicroorganisms · 2021Article
- A Ribosome Interaction Surface Sensitive to mRNA GCN Periodicity.Biomolecules · 2020Article
- GCN sensitive protein translation in yeast.PloS one · 2020Article
- Chromatin-sensitive cryptic promoters putatively drive expression of alternative protein isoforms in yeast.Genome research · 2019Article
- Non-canonical translation initiation in yeast generates a cryptic pool of mitochondrial proteins.Nucleic acids research · 2019Article
- N-terminal Proteomics Assisted Profiling of the Unexplored Translation Initiation Landscape in Arabidopsis thaliana.Molecular & cellular proteomics : MCP · 2017Article
- N-Terminal Peptide Detection with Optimized Peptide-Spectrum Matching and Streamlined Sequence Libraries.Journal of proteome research · 2016Article
- Landscape and Dynamics of Transcription Initiation in the Malaria Parasite Plasmodium falciparum.Cell reports · 2016Article
- Article
- Mining proteomic data to expose protein modifications in Methanosarcina mazei strain Gö1.Frontiers in microbiology · 2015Article
- Investigation of phycobilisome subunit interaction interfaces by coupled cross-linking and mass spectrometry.The Journal of biological chemistry · 2014Article
- Assessment of MS/MS search algorithms with parent-protein profiling.Journal of proteome research · 2014Article
- Ribosome profiling: new views of translation, from single codons to genome scale.Nature reviews. Genetics · 2014Review
- Constitutive and nitrogen catabolite repression-sensitive production of Gat1 isoforms.The Journal of biological chemistry · 2014Article
- Roles for transcript leaders in translation and mRNA decay revealed by transcript leader sequencing.Genome research · 2013Article
- Article
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7 authors.
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Abstract
Comprehensive knowledge of proteome complexity is crucial to understanding cell function. Amino termini of yeast proteins were identified through peptide mass spectrometry on glutaraldehyde-treated cell lysates as well as a parallel assessment of publicly deposited spectra. An unexpectedly large fraction of detected amino-terminal peptides (35%) mapped to translation initiation at AUG codons downstream of the annotated start codon. Many of the implicated genes have suboptimal sequence contexts for translation initiation near their annotated AUG, and their ribosome profiles show elevated tag densities consistent with translation initiation at downstream AUGs as well as their annotated AUGs. These data suggest that a significant fraction of the yeast proteome derives from initiation at downstream AUGs, increasing significantly the repertoire of encoded proteins and their potential functions and cellular localizations.
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