Evidence map›Paper›PMID 23140091›Full record

SynthesisActa orthopaedica2012

Early migration of tibial components is associated with late revision: a systematic review and meta-analysis of 21,000 knee arthroplasties.

Bart G Pijls, Edward R Valstar, Klaas-Auke Nouta, Josepha Wm Plevier, Marta Fiocco, Saskia Middeldorp, Rob Ghh Nelissen

6 registry-linked trialsOpen access · goldAbstract readComparative StudyMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Acta orthopaedica, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 6 registered trials, which are not on this map. Cited by 105 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 8 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01971931 completednot on this mapstarted 2013, after this paper: background citation

Prospective Evaluation of Biomarkers Variability in Knee Prosthetic Surgery

TypeobservationalSponsorUniversity of MilanRan2013 to 2017Enrolled40ConditionsKnee Osteoarthritis
NCT02373761 unknown statusnot on this mapstarted 2015, after this paper: background citation

A Prospective Radiostereometric Analysis (RSA) and Clinical Evaluation of the Triathlon Tritanium Total Knee Replacement

Typeobservational_patient_registrySponsorScott SporerRan2015Enrolled27ConditionsOsteoarthritis of the KneeArmsStryker Triathlon Tritanium primary knee
NCT02861794 nacompletednot on this mapstarted 2016, after this paper: background citation

Evaluation of Early Migration of Medially Stabilized Arthroplasty as a Predictor of Long Time Survivorship (Implant Design Study)

TypeinterventionalSponsorOslo University HospitalRan2016 to 2024Enrolled44ConditionsKnee OsteoarthritisArmsMedacta International, GMK Sphere medially stabilized knee
NCT02965690 naunknown statusnot on this mapstarted 2016, after this paper: background citation

Comparison of in Vivo Kinematics of Different Implants in ACL-sacrificing vs. Medially Stabilized Arthroplasty (Implant Design Study)

TypeinterventionalSponsorOslo University HospitalRan2016 to 2025Enrolled26ConditionsKnee OsteoarthritisArmsZimmer Biomet NexGen CR, Medacta International GMK Sphere
NCT04017533 nacompletednot on this mapstarted 2021, after this paper: background citation

In Vivo Stability of an Uncemented Total Knee Arthroplasty With Medially Stabilized Design

TypeinterventionalSponsorOslo University HospitalRan2021 to 2024Enrolled31ConditionsKnee OsteoarthritisArmsGMK Sphere TKR
NCT06507046 narecruitingnot on this mapstarted 2024, after this paper: background citation

Robotic Assisted Surgery Comparing Personalized Alignment Versus Mechanical Alignment of Total Knee Arthroplasty - A Randomized Controlled Trial

TypeinterventionalSponsorHelse Møre og Romsdal HFRan2024 to 2035Enrolled152ConditionsKnee OsteoarthritisArmsTotal knee replacement
3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 8 syntheses or guidelines pooled it, 198 citations in OpenAlex.

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45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Bart G PijlsDepartment of Orthopaedics, Bio Imaging Group, Leiden University Medical Center, Leiden, the Netherlands. b.g.c.w.pijls@lumc.nl
Edward R Valstar
Klaas-Auke Nouta
Josepha Wm Plevier
Marta Fiocco
Saskia Middeldorp
Rob Ghh Nelissen
Leiden University Medical Center · NLCalifornia Maritime Academy · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe performed two parallel systematic reviews and meta-analyses to determine the association between early migration of tibial components and late aseptic revision.

methodsOne review comprised early migration data from radiostereometric analysis (RSA) studies, while the other focused on revision rates for aseptic loosening from long-term survival studies. Thresholds for acceptable and unacceptable migration were determined according to that of several national joint registries: < 5% revision at 10 years.

resultsFollowing an elaborate literature search, 50 studies (involving 847 total knee prostheses (TKPs)) were included in the RSA review and 56 studies (20,599 TKPs) were included in the survival review. The results showed that for every mm increase in migration there was an 8% increase in revision rate, which remained after correction for age, sex, diagnosis, hospital type, continent, and study quality. Consequently, migration up to 0.5 mm was considered acceptable during the first postoperative year, while migration of 1.6 mm or more was unacceptable. TKPs with migration of between 0.5 and 1.6 mm were considered to be at risk of having revision rates higher than 5% at 10 years.

interpretationThere was a clinically relevant association between early migration of TKPs and late revision for loosening. The proposed migration thresholds can be implemented in a phased, evidence-based introduction of new types of knee prostheses, since they allow early detection of high-risk TKPs while exposing only a small number of patients.

Indexed as

Knee ProsthesisProsthesis FailureAgedArthroplasty, Replacement, KneeFemaleFollow-Up StudiesHumansIncidenceMaleMiddle AgedNetherlandsProsthesis DesignReoperationRisk AssessmentTime FactorsTreatment Outcome

Identifiers

PMID23140091
PMCPMC3555454
OpenAlexW2011852138

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.