ArticleScientific reports2012
A chemical genomic study identifying diversity in cell migration signaling in cancer cells.
Article in Scientific reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Exploring Water-Soluble South AfricanCurrent issues in molecular biology · 2024Article
- Review
- A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers.Autophagy · 2021Article
- Collective Polarization of Cancer Cells at the Monolayer Boundary.Micromachines · 2021Article
- Inhibition of SHP2 by new compounds induces differential effects on RAS/RAF/ERK and PI3K/AKT pathways in different cancer cell types.Investigational new drugs · 2019Article
- Novel anti-cancer agent myrtucommulone-A and thymoquinone abrogate epithelial-mesenchymal transition in cancer cells mainly through the inhibition of PI3K/AKT signalling axis.Molecular and cellular biochemistry · 2016Article
- 5-Lipoxygenase and cysteinyl leukotriene receptor 1 regulate epidermal growth factor-induced cell migration through Tiam1 upregulation and Rac1 activation.Cancer science · 2014Article
- Chemical genomic-based pathway analyses for epidermal growth factor-mediated signaling in migrating cancer cells.PloS one · 2014Article
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Authors and funding
3 authors.
Funding
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Abstract
The aim of this study was to analyze the diversity and consistency of regulatory signaling in cancer cell migration, using a chemical genomic approach. The effects of 34 small molecular compounds were assessed quantitatively by wound healing assay in ten types of migrating cells. Hierarchical clustering was performed on the subsequent migration inhibition profile of the compounds and cancer cell types. The result was that hierarchical clustering accurately classified the compounds according to their targets. Furthermore, the cancer cells tested in this study were classified into three clusters, and the compounds were grouped into four clusters. An inhibitor of JNK suppressed all types of cell migration; however, inhibitors of ROCK, GSK-3 and p38MAPK only inhibited the migration of a subset of cell lines. Thus, our analytical system could easily distinguish between the common and cell type-specific signals responsible for cell migration.
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