ArticlePloS one2012
Reduction of type IV collagen by upregulated miR-29 in normal elderly mouse and klotho-deficient, senescence-model mouse.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 47 citations in OpenAlex.
- Mir-29 repression in bladder outlet obstruction contributes to matrix remodeling and altered stiffness.PloS one · 2013Trial
- The life cycle of type IV collagen.Matrix biology : journal of the International Society for Matrix Biology · 2025Review
- miRNA-29 regulates epidermal and mesenchymal functions in skin repair.FEBS letters · 2025Article
- Mir-509-3p targets SLC25A13 to regulate ferroptosis and protect retinal endothelial cells in diabetic retinopathy.Acta diabetologica · 2025Article
- Identification of Oncogene-Induced Senescence-Associated MicroRNAs.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Downregulation ofCurrent diabetes reviews · 2025Article
- Regulating translation in aging: from global to gene-specific mechanisms.EMBO reports · 2024Review
- A chimeric RNA consisting of siRNA and aptamer for inhibiting dengue virus replication.NAR molecular medicine · 2024Article
- miR-29 is an important driver of aging-related phenotypes.Communications biology · 2024Article
- Expression of TNFR1, VEGFA, CD147 and MCT1 as early biomarkers of diabetes complications and the impact of aging on this profile.Scientific reports · 2023Article
- MiR-199-3p enhances muscle regeneration and ameliorates aged muscle and muscular dystrophy.Communications biology · 2021Article
- Article
- Review
- A miRNA catalogue and ncRNA annotation of the short-living fish Nothobranchius furzeri.BMC genomics · 2017Article
- MicroRNA miR-29 controls a compensatory response to limit neuronal iron accumulation during adult life and aging.BMC biology · 2017Article
- Human umbilical cord-derived mesenchymal stromal cells protect against premature renal senescence resulting from oxidative stress in rats with acute kidney injury.Stem cell research & therapy · 2017Article
- Vascular Aging: Implications for Cardiovascular Disease and Therapy.Translational medicine (Sunnyvale, Calif.) · 2016Article
- Chronic miR-29 antagonism promotes favorable plaque remodeling in atherosclerotic mice.EMBO molecular medicine · 2016Article
- ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases.Oxidative medicine and cellular longevity · 2016Review
- MicroRNAs and lncRNAs in senescence: A re-view.IUBMB life · 2015Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNA (miRNA), a small non-coding RNA that functions as a mediator in gene silencing, plays important roles in gene regulation in various vital functions and activities. Here we show that the miR-29 members are upregulated in klotho-deficient [klotho(-/-)] mice, a senescence-model animal, and also in normal elderly ICR mice relative to wild-type littermates and young ICR mice. In addition, levels of type IV collagen, a major component of basement membranes and a putative target of miR-29, were lower in klotho(-/-) and elderly ICR mice than in wild-type littermates and young ICR mice. RNA degradation mediated by miR-29 may participate in the suppression of type IV collagen, both in vivo and in vitro. Taken together, our current findings suggest that the miR-29 upregulated in aging may be involved in the downregulation of type IV collagen, leading to a possible weakening of the basal membrane in senescent tissues, and miR-29 may be a useful molecular marker of senescence.
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