ArticlePloS one2012
Polycomb group proteins bind an engrailed PRE in both the "ON" and "OFF" transcriptional states of engrailed.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- Polycomb Group Proteins inBiology · 2026Review
- Article
- Polycomb protein binding and looping in the ON transcriptional state.Science advances · 2024Article
- Polycomb protein binding and looping mediated by Polycomb Response Elements in the ON transcriptional state.bioRxiv : the preprint server for biology · 2023Article
- Context-dependent role of Pho binding sites in Polycomb complex recruitment in Drosophila.Genetics · 2023Article
- Variant Polycomb complexes inScience advances · 2022Article
- Boundaries potentiate polycomb response element-mediated silencing.BMC biology · 2021Article
- Functions of Polycomb Proteins on Active Targets.Epigenomes · 2020Review
- Activity of PRC1 and Histone H2AK119 Monoubiquitination: Revising Popular Misconceptions.BioEssays : news and reviews in molecular, cellular and developmental biology · 2020Review
- RNA-DNA strand exchange by the Drosophila Polycomb complex PRC2.Nature communications · 2020Article
- Structure and function of an ectopic Polycomb chromatin domain.Science advances · 2019Article
- Regulation and function of H3K36 di-methylation by the trithorax-group protein complex AMC.Development (Cambridge, England) · 2018Article
- Global changes of H3K27me3 domains and Polycomb group protein distribution in the absence of recruiters Spps or Pho.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Bivalent complexes of PRC1 with orthologs of BRD4 and MOZ/MORF target developmental genes inGenes & development · 2017Article
- Formation of a Polycomb-Domain in the Absence of Strong Polycomb Response Elements.PLoS genetics · 2016Article
- Combgap contributes to recruitment of Polycomb group proteins in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Checks and balances between cohesin and polycomb in gene silencing and transcription.Current biology : CB · 2014Article
- What are memories made of? How Polycomb and Trithorax proteins mediate epigenetic memory.Nature reviews. Molecular cell biology · 2014Review
- High-resolution mapping defines the cooperative architecture of Polycomb response elements.Genome research · 2014Article
- A genetic approach to the recruitment of PRC2 at the HoxD locus.PLoS genetics · 2013Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Polycomb group (PcG) and trithorax Group (trxG) proteins maintain the "OFF" and "ON" transcriptional states of HOX genes and other targets by modulation of chromatin structure. In Drosophila, PcG proteins are bound to DNA fragments called Polycomb group response elements (PREs). The prevalent model holds that PcG proteins bind PREs only in cells where the target gene is "OFF". Another model posits that transcription through PREs disrupts associated PcG complexes, contributing to the establishment of the "ON" transcriptional state. We tested these two models at the PcG target gene engrailed. engrailed exists in a gene complex with invected, which together have 4 well-characterized PREs. Our data show that these PREs are not transcribed in embryos or larvae. We also examined whether PcG proteins are bound to an engrailed PRE in cells where engrailed is transcribed. By FLAG-tagging PcG proteins and expressing them specifically where engrailed is "ON" or "OFF", we determined that components of three major PcG protein complexes are present at an engrailed PRE in both the "ON" and "OFF" transcriptional states in larval tissues. These results show that PcG binding per se does not determine the transcriptional state of engrailed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.