ArticlePloS one2012
HLA-DRB1 alleles are associated with the susceptibility to sporadic Parkinson's disease in Chinese Han population.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Human leukocyte antigen in Parkinson's disease: A systematic review and meta-analysis of risk and clinical attributes.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Pooled it
- Pooled analysis of the HLA-DRB1 by smoking interaction in Parkinson disease.Annals of neurology · 2017Pooled it
- A specific amino acid motif ofProceedings of the National Academy of Sciences of the United States of America · 2019Trial
- Association between Human Leukocyte Antigen Alleles and Neuropathological Outcomes in Lewy Body Disease.Annals of neurology · 2026Article
- Human Leukocyte Antigen Polymorphism and Blood Biomarker Profiles in Parkinson's Disease: A Pilot Study in a Latvian Cohort.Biomedicines · 2024Article
- Regulatory SVA retrotransposons and classical HLA genotyped-transcripts associated with Parkinson's disease.Frontiers in immunology · 2024Article
- Quantitative and causal analysis for inflammatory genes and the risk of Parkinson's disease.Frontiers in immunology · 2023Article
- Fine mapping of the HLA locus in Parkinson's disease in Europeans.NPJ Parkinson's disease · 2021Article
- Immunogenetic Epidemiology of Dementia and Parkinson's Disease in 14 Continental European Countries: Shared Human Leukocyte Antigen (HLA) Profiles.Journal of immunological sciences · 2021Article
- Genetic and Environmental Factors in Parkinson's Disease Converge on Immune Function and Inflammation.Movement disorders : official journal of the Movement Disorder Society · 2021Review
- New Insights into Immune-Mediated Mechanisms in Parkinson's Disease.International journal of molecular sciences · 2020Review
- Parkinson disease and the immune system - associations, mechanisms and therapeutics.Nature reviews. Neurology · 2020Review
- T-Cell-Driven Inflammation as a Mediator of the Gut-Brain Axis Involved in Parkinson's Disease.Frontiers in immunology · 2019Review
- The immunogenetics of neurological disease.Immunology · 2018Review
- Autoimmune Hepatitis in the East and the West.Inflammatory intestinal diseases · 2017Article
- The Potential Mutation of GAK Gene in the Typical Sporadic Parkinson's Disease from the Han Population of Chinese Mainland.Molecular neurobiology · 2016Article
- The biomarkers of immune dysregulation and inflammation response in Parkinson disease.Translational neurodegeneration · 2016Review
- Regulation of the Neurodegenerative Process Associated to Parkinson's Disease by CD4+ T-cells.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2015Review
- Role of α-synuclein in inducing innate and adaptive immunity in Parkinson disease.Journal of Parkinson's disease · 2015Review
- Genetic insights into sporadic Parkinson's disease pathogenesis.Current genomics · 2013Article
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Authors and funding
11 authors.
Funding
Abstract
Immune disorders may play an important role in the pathogenesis of Parkinson's disease (PD). Recently, polymorphisms in the HLA-DR region have been found to be associated with sporadic PD in European ancestry populations. However, polymorphisms in the HLA complex are highly variable with ethnic and geographic origin. To explore the relationships between polymorphisms of the HLA-DR region and sporadic PD in Chinese Han population, we genotyped 567 sporadic PD patients and 746 healthy controls in two independent series for the HLA-DRB1 locus with Polymerase chain reaction-sequence based typing(PCR-SBT). The χ(2) test was used to evaluate the distribution of allele frequencies between the patients and healthy controls. The impact of HLA-DRB1 alleles on PD risk was estimated by unconditional logistic regression. We found a significant higher frequency of HLA-DRB1*0301 in sporadic PD patients than in healthy controls and a positive association, which was independent of onset age, between HLA-DRB1*0301 and PD risk. Conversely, a lower frequency of HLA-DRB1*0406 was found in sporadic PD patients than in healthy controls, with a negative association between HLA-DRB1*0406 and PD risk. Furthermore, a meta-analysis involving 195205 individuals was conducted to summarize the frequencies of these two alleles in populations from various ethnic regions, we found a higher frequency of HLA-DRB1*0301, but a lower frequency of HLA-DRB1*0406 in European ancestry populations than that in Asians, this was consistent with the higher prevalence of sporadic PD in European ancestry populations. Based on these results, we speculate that HLA-DRB1 alleles are associated with the susceptibility to sporadic PD in Chinese Han population, among them HLA-DRB1*0301 is a risk allele while the effect of HLA-DRB1*0406 deserves debate.
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