ReviewMolecular human reproduction2013
Maternal smoking as a model for environmental epigenetic changes affecting birthweight and fetal programming.
Review in Molecular human reproduction, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 3 syntheses or guidelines pooled it, 86 citations in OpenAlex.
- The Effects of E-Cigarette Vapor Components on the Morphology and Function of the Male and Female Reproductive Systems: A Systematic Review.International journal of environmental research and public health · 2020Pooled it
- Association between maternal smoking and child bone mineral density: a systematic review and meta-analysis.Environmental science and pollution research international · 2020Pooled it
- Chained Risk Assessment for Life-Long Disease Burden of Early Exposures - Demonstration of Concept Using Prenatal Maternal Smoking.International journal of environmental research and public health · 2020Pooled it
- Machine learning-enhanced surface-enhanced spectroscopic detection of polycyclic aromatic hydrocarbons in the human placenta.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- NeonatalToxics · 2023Article
- Review
- Attitude and Practice Toward Use of Cigarettes and Electronic Cigarettes Among Pregnant Women: A Questionnaire-Based Survey.Turkish thoracic journal · 2022Article
- Maternal and early life exposures and their potential to influence development of the microbiome.Genome medicine · 2022Review
- Predictive models for small-for-gestational-age births in women exposed to pesticides before pregnancy based on multiple machine learning algorithms.Frontiers in public health · 2022Article
- Validation of differential DNA methylation in newborns exposed to tobacco smoke during gestation using bisulfite pyrosequencing.microPublication biology · 2022Article
- Perinatal exposure to nicotine alters spermatozoal DNA methylation near genes controlling nicotine action.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Epigenetic Alterations of Maternal Tobacco Smoking during Pregnancy: A Narrative Review.International journal of environmental research and public health · 2021Review
- DNA Methylation in Babies Born to Nonsmoking Mothers Exposed to Secondhand Smoke during Pregnancy: An Epigenome-Wide Association Study.Environmental health perspectives · 2021Article
- The impact of tobacco chemicals and nicotine on placental development.Prenatal diagnosis · 2020Review
- Fetal exposure to maternal active and secondhand smoking with offspring early-life growth in the Healthy Start study.International journal of obesity (2005) · 2019Article
- On the Nature of Evidence and 'Proving' Causality: Smoking and Lung Cancer vs. Sun Exposure, Vitamin D and Multiple Sclerosis.International journal of environmental research and public health · 2018Article
- Article
- Self-reported prenatal tobacco smoke exposure, AXL gene-body methylation, and childhood asthma phenotypes.Clinical epigenetics · 2018Article
- The Epigenetics of Intrauterine Smoke Exposure: Can Maternal Vitamin C Supplementation Prevent Neonatal Respiratory Disease?American journal of respiratory and critical care medicine · 2017Article
- Plausible Roles for RAGE in Conditions Exacerbated by Direct and Indirect (Secondhand) Smoke Exposure.International journal of molecular sciences · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Although the association between maternal smoking and low birthweight infants has been well established, the mechanisms behind reduced fetal growth are still being elucidated. While many infants are exposed to tobacco smoke in utero, not all are born growth restricted or small for gestational age. Many hypotheses have emerged to explain the differential response to in utero maternal tobacco smoke exposure (MTSE). Studies have shown that both maternal and fetal genotypes may contribute to the discrepant outcomes. However, the contribution of epigenetic changes cannot be ignored. In this review we address two important questions regarding the effect of MTSE on the fetal epigenome. First, does exposure to maternal tobacco smoke in utero alter the fetal epigenome? Secondly, could these alterations be associated with the reduced fetal growth observed with MTSE?
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.