ArticleJournal of applied physiology (Bethesda, Md. : 1985)2013
The impact of arousal state, sex, and sleep apnea on the magnitude of progressive augmentation and ventilatory long-term facilitation.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00860743 (Respiratory and Autonomic Plasticity Following Intermittent Hypoxia), which is not on this map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Respiratory and Autonomic Plasticity Following Intermittent Hypoxia
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- The hypoxic ventilatory response and arousal burden predict the magnitude of ventilatory long-term facilitation in humans with obstructive sleep apnoea.Experimental physiology · 2026Pooled it
- The hypoxic ventilatory response and hypoxic burden are predictors of the magnitude of ventilatory long-term facilitation in humans.The Journal of physiology · 2023Pooled it
- Does trans-spinal direct current stimulation alter phrenic motoneurons and respiratory neuromechanical outputs in humans? A double-blind, sham-controlled, randomized, crossover study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Trial
- Long-term facilitation of ventilation in humans with chronic spinal cord injury.American journal of respiratory and critical care medicine · 2014Trial
- Diurnal cycle and acute intermittent hypoxia protocol interact to regulate ventilatory long-term facilitation in unanesthetized rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Article
- Intermittent hypoxia: a call for harmonization in terminology.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- International Consensus Statement on Obstructive Sleep Apnea.International forum of allergy & rhinology · 2023Review
- Divergent Ventilatory and Blood Pressure Responses are Evident Following Repeated Daily Exposure to Mild Intermittent Hypoxia in Males with OSA and Hypertension.Frontiers in physiology · 2022Article
- Pathophysiology of Obstructive Sleep Apnea in Aging Women.Current sleep medicine reports · 2021Article
- A comprehensive review of respiratory, autonomic and cardiovascular responses to intermittent hypoxia in humans.Experimental neurology · 2021Review
- Baseline Arterial COFrontiers in physiology · 2021Article
- Variations in loop gain and arousal threshold during NREM sleep are affected by time of day over a 24-hour period in participants with obstructive sleep apnea.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Circadian clock genes and respiratory neuroplasticity genes oscillate in the phrenic motor system.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Increased Oxidative Stress, Loop Gain And The Arousal Threshold Are Clinical Predictors Of Increased Apnea Severity Following Exposure To Intermittent Hypoxia.Nature and science of sleep · 2019Article
- Daytime loop gain is elevated in obstructive sleep apnea but not reduced by CPAP treatment.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Article
- Pathophysiology of central sleep apneas.Sleep & breathing = Schlaf & Atmung · 2016Review
- Power spectral analysis of hypoglossal nerve activity during intermittent hypoxia-induced long-term facilitation in mice.Journal of neurophysiology · 2016Article
- Intermittent hypoxia and neurorehabilitation.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
We examined the impact of arousal state, sex, and obstructive sleep apnea (OSA) on the magnitude of progressive augmentation of the hypoxic ventilatory response and ventilatory long-term facilitation (vLTF). We also examined whether exposure to intermittent hypoxia during sleep has an impact on the apnea-hypopnea index (AHI) in individuals with OSA. Ten men and seven women with OSA, along with ten healthy men and ten healthy women, were exposed to twelve 2-min episodes of hypoxia (end-tidal PO(2): 50 Torr) in the presence of sustained hypercapnia (end-tidal PCO(2): 3 Torr above baseline), followed by a 30-min recovery period during wakefulness and sleep. The OSA participants completed an additional sham study during sleep. The AHI during the first hour of sleep following the intermittent hypoxia and sham protocols were compared. Progressive augmentation was only evident during wakefulness and was enhanced in the OSA participants. vLTF was evident during wakefulness and sleep. When standardized to baseline, vLTF was greater during wakefulness and was enhanced in the OSA group (men: wakefulness 1.39 ± 0.08 vs. sleep 1.14 ± 0.03; women: wakefulness 1.35 ± 0.03 vs. sleep 1.16 ± 0.05 fraction of baseline; P ≤ 0.001) compared with control (men: wakefulness 1.19 ± 0.03 vs. sleep 1.09 ± 0.03; women: wakefulness 1.26 ± 0.05 vs. sleep 1.08 ± 0.04 fraction of baseline; P ≤ 0.001). The AHI following exposure to intermittent hypoxia was increased (intermittent hypoxia 72.8 ± 7.3 vs. sham 56.5 ± 7.0 events/h; P ≤ 0.01). Sex-related differences were not observed for the primary measures. We conclude that progressive augmentation is not evident, and the magnitude of vLTF is diminished during sleep compared with wakefulness in men and women. However, when present, the phenomena are enhanced in individuals with OSA. The AHI data indicate that, under the prevailing experimental conditions, vLTF did not serve to mitigate apnea severity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.