ArticleDiabetes2013
White matter microstructural integrity in youth with type 1 diabetes.
Article in Diabetes, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
51 citing papers in PubMed, 92 citations in OpenAlex.
- Clinical Trial of Fluid Infusion Rates for Pediatric Diabetic Ketoacidosis.The New England journal of medicine · 2018Trial
- Brain functional abnormalities: a bridge between insulin signaling pathway gene polymorphisms and clinical cognition in early-onset obsessive-compulsive disorder.European child & adolescent psychiatry · 2026Article
- The Impact of Diabetes on Brain Health in Childhood.Biomedicines · 2026Review
- Article
- Neurocognitive profile of the adult population living with type 1 diabetes mellitus: a matched case-control cross-sectional study of metabolism and memory.Frontiers in endocrinology · 2025Article
- The impact of type 1 diabetes mellitus on intellectual status: A Mendelian randomization study.Journal of education and health promotion · 2025Article
- Diabetic Encephalopathy: Role of Oxidative and Nitrosative Factors in Type 2 Diabetes.Indian journal of clinical biochemistry : IJCB · 2024Review
- Neuropsychological Aspects of Children's Somatic Disorders in Chronic Diseases: Diabetes and Short Stature in the Developmental Period.Biomedicines · 2023Article
- Exploratory Multisite MR Spectroscopic Imaging Shows White Matter Neuroaxonal Loss Associated with Complications of Type 1 Diabetes in Children.AJNR. American journal of neuroradiology · 2023Article
- Altered gray matter volume in children with newly diagnosed type 1 diabetes mellitus.Pediatric research · 2023Article
- Missed meal boluses and poorer glycemic control impact on neurocognitive function may be associated with white matter integrity in adolescents with type 1 diabetes.Frontiers in endocrinology · 2023Article
- Interaction of network and rehabilitation therapy parameters in defining recovery after stroke in a Bilateral Neural Network.Journal of neuroengineering and rehabilitation · 2022Article
- Effects of the timing of the initiation of dietary intake on pediatric type 1 diabetes for diabetic ketoacidosis.BMC pediatrics · 2022Article
- Impact of glucose metabolism on the developing brain.Frontiers in endocrinology · 2022Review
- Impact of Type 1 Diabetes in the Developing Brain in Children: A Longitudinal Study.Diabetes care · 2021Article
- Investigating Brain Microstructural Alterations in Type 1 and Type 2 Diabetes Using Diffusion Tensor Imaging: A Systematic Review.Brain sciences · 2021Review
- Oxidative-Antioxidant Imbalance and Impaired Glucose Metabolism in Schizophrenia.Biomolecules · 2020Review
- Abnormal Functional Connectivity Density in New-Onset Type 1 Diabetes Mellitus Children: A Resting-State Functional Magnetic Resonance Imaging Study.Frontiers in psychiatry · 2020Article
- Serum Neuron-specific Enolase and S100 Calcium-binding Protein B in Pediatric Diabetic KetoacidosisJournal of clinical research in pediatric endocrinology · 2019Article
- Abnormal corpus callosum induced by diabetes impairs sensorimotor connectivity in patients after acute stroke.European radiology · 2019Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Decreased white and gray matter volumes have been reported in youth with type 1 diabetes mellitus (T1DM), but the effects of hyperglycemia on white matter integrity have not been quantitatively assessed during brain development. We performed diffusion tensor imaging, using two complimentary approaches--region-of-interest and voxelwise tract-based spatial statistics--to quantify white matter integrity in a large retrospective study of T1DM youth and control participants. Exposure to chronic hyperglycemia, severe hyperglycemic episodes, and severe hypoglycemia, as defined in the Diabetes Control and Complications Trial (DCCT), were estimated through medical records review, HbA(1c) levels, and interview of parents and youth. We found lower fractional anisotropy in the superior parietal lobule and reduced mean diffusivity in the thalamus in the T1DM group. A history of three or more severe hyperglycemic episodes was associated with reduced anisotropy and increased diffusivity in the superior parietal lobule and increased diffusivity in the hippocampus. These results add microstructural integrity of white matter to the range of structural brain alterations seen in T1DM youth and suggest vulnerability of the superior parietal lobule, hippocampus, and thalamus to glycemic extremes during brain development. Longitudinal analyses will be necessary to determine how these alterations change with age or additional glycemic exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.