ArticleInvestigative ophthalmology & visual science2012
Temporal development of retinal arteriolar endothelial dysfunction in porcine type 1 diabetes.
Article in Investigative ophthalmology & visual science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 37 citations in OpenAlex.
- Investigational New Drug-enabling studies in a human vessel-chip: Are we there yet?Bioengineering & translational medicine · 2026Review
- Pig Models in Retinal Research and Retinal Disease.Cold Spring Harbor perspectives in medicine · 2024Review
- The Association between Diabetic Retinopathy and Macular Degeneration: A Nationwide Population-Based Study.Biomedicines · 2024Article
- HInternational journal of molecular sciences · 2022Article
- Beneficial Effect of Long-Term Administration of Supplement With Trapa Bispinosa Roxb. and Lutein on Retinal Neurovascular Coupling in Type 2 Diabetic Mice.Frontiers in physiology · 2022Article
- Structural changes in the retina after implantation of subretinal three-dimensional implants in mini pigs.Frontiers in neuroscience · 2022Article
- Article
- Retinal blood flow dysregulation precedes neural retinal dysfunction in type 2 diabetic mice.Scientific reports · 2021Article
- An experimental pig model with outer retinal degeneration induced by temporary intravitreal loading of N-methyl-N-nitrosourea during vitrectomy.Scientific reports · 2021Article
- Hyperglycemia Augments Endothelin-1-Induced Constriction of Human Retinal Venules.Translational vision science & technology · 2020Article
- Retinal Physiology and Circulation: Effect of Diabetes.Comprehensive Physiology · 2020Review
- Smart Microneedles with Porous Polymer Layer for Glucose-Responsive Insulin Delivery.Pharmaceutics · 2020Article
- Role of Arginase in Selective Impairment of Endothelium-Dependent Nitric Oxide Synthase-Mediated Dilation of Retinal Arterioles during Early Diabetes.Investigative ophthalmology & visual science · 2020Article
- Morphological and pharmacological characterization of the porcine popliteal artery: A novel model for study of lower limb arterial disease.Microcirculation (New York, N.Y. : 1994) · 2019Article
- Hyperglycemia Enhances Constriction of Retinal Venules via Activation of the Reverse-Mode Sodium-Calcium Exchanger.Diabetes · 2019Article
- Organ-on-chips made of blood: endothelial progenitor cells from blood reconstitute vascular thromboinflammation in vessel-chips.Lab on a chip · 2019Article
- Requisite roles of LOX-1, JNK, and arginase in diabetes-induced endothelial vasodilator dysfunction of porcine coronary arterioles.Journal of molecular and cellular cardiology · 2019Article
- Correlation of spectral domain optical coherence tomography with histology and electron microscopy in the porcine retina.Experimental eye research · 2018Article
- Constriction of Retinal Venules to Endothelin-1: Obligatory Roles of ETA Receptors, Extracellular Calcium Entry, and Rho Kinase.Investigative ophthalmology & visual science · 2018Article
- Diabetic retinopathy: Breaking the barrier.Pathophysiology : the official journal of the International Society for Pathophysiology · 2017Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
purposeAlthough hyperglycemia is implicated in retinal vascular dysfunction associated with the development of diabetic retinopathy, the temporal influence of hyperglycemia on retinal arteriolar reactivity remains unclear. Development of a large animal model of diabetes relevant to the human retina for evaluation of vascular function is also lacking. Herein, we examined nitric oxide (NO)-mediated dilation and endothelin-1 (ET-1)-induced constriction in retinal arterioles at various time periods in a porcine model of type 1 diabetes.
methodsRetinal arterioles were isolated from streptozocin-induced diabetic pigs (2, 6, and 12 weeks of hyperglycemia, 427 ± 23 mg/dL) and age-matched control pigs (73 ± 4 mg/dL), and then cannulated and pressurized for vasoreactivity study using videomicroscopic techniques.
resultsRetinal arterioles isolated from control and diabetic pigs developed comparable levels of myogenic tone. The endothelium-dependent NO-mediated vasodilations to bradykinin and stepwise increases in luminal flow were significantly reduced within 2 weeks of hyperglycemia. The inhibitory effect was comparable following 6 and 12 weeks of hyperglycemia. However, the endothelium-independent vasodilation to sodium nitroprusside was unaffected. Constriction of retinal arterioles to ET-1 was unaltered at all time periods of hyperglycemia.
conclusionsOur findings provide the first direct evidence for selective impairment of endothelium-dependent NO-mediated dilation of retinal arterioles within 2 weeks of hyperglycemia in a pig model of diabetes. By contrast, the ability of arteriolar smooth muscle to dilate to NO donor or contract to ET-1 was unaffected throughout the study period. This endothelial vasodilator dysfunction during early diabetes may contribute to development of retinopathy with chronic hyperglycemia.
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