ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2013
Modulation of the gut microbiota with antibiotic treatment suppresses whole body urea production in neonatal pigs.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 43 citations in OpenAlex.
- Review
- Impacts of 360 mg/kg Niacinamide Supplementation in Low-Protein Diets on Energy and Nitrogen Metabolism and Intestinal Microbiota in Growing-Finishing Pigs.Animals : an open access journal from MDPI · 2025Article
- Behavioral alterations in antibiotic-treated mice associated with gut microbiota dysbiosis: insights from 16S rRNA and metabolomics.Frontiers in neuroscience · 2025Article
- Therapeutic strategies to modulate gut microbial health: Approaches for sarcopenia management.Histology and histopathology · 2024Review
- The Research Progress on the Interaction between Mammalian Gut Microbiota and the Host's Metabolism Homeostasis during Hibernation.Metabolites · 2024Review
- Probiotics in piglet: from gut health to pathogen defense mechanisms.Frontiers in immunology · 2024Review
- Donor-dependent fecal microbiota transplantation efficacy against necrotizing enterocolitis in preterm pigs.NPJ biofilms and microbiomes · 2022Article
- Free threonine in human breast milk is related to infant intestinal microbiota composition.Amino acids · 2022Article
- Timely Control of Gastrointestinal Eubiosis: A Strategic Pillar of Pig Health.Microorganisms · 2021Review
- Swine gut microbiota and its interaction with host nutrient metabolism.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2020Review
- Effects of Dietary Crude Protein Levels on Fecal Crude Protein, Amino Acids Flow Amount, Fecal and Ileal Microbial Amino Acids Composition and Amino Acid Digestibility in Growing Pigs.Animals : an open access journal from MDPI · 2020Article
- Impact of Protein Intake in Older Adults with Sarcopenia and Obesity: A Gut Microbiota Perspective.Nutrients · 2020Review
- Effects of Three Distinct 2-Week Long Diet Strategies After Transport on Weaned Pigs' Short and Long-Term Welfare Markers, Behaviors, and Microbiota.Frontiers in veterinary science · 2020Article
- Effects of dietary supplementation of probiotic Enterococcus faecium on growth performance and gut microbiota in weaned piglets.AMB Express · 2019Article
- Effects of Early Intervention With Maternal Fecal Bacteria and Antibiotics on Liver Metabolome and Transcription in Neonatal Pigs.Frontiers in physiology · 2019Article
- Diet, Gut Microbiota, and Obesity: Links with Host Genetics and Epigenetics and Potential Applications.Advances in nutrition (Bethesda, Md.) · 2019Review
- Antibiotic-mediated bacteriome depletion in ApcCancer medicine · 2018Article
- Gut Dysbiosis and Muscle Aging: Searching for Novel Targets against Sarcopenia.Mediators of inflammation · 2018Review
- Long-term effects of early antibiotic intervention on blood parameters, apparent nutrient digestibility, and fecal microbial fermentation profile in pigs with different dietary protein levels.Journal of animal science and biotechnology · 2017Article
- Metabolic profiling of a chronic kidney disease cohort reveals metabolic phenotype more likely to benefit from a probiotic.International journal of probiotics & prebiotics · 2017Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 4 countries.
Funding
Abstract
We examined whether changes in the gut microbiota induced by clinically relevant interventions would impact the bioavailability of dietary amino acids in neonates. We tested the hypothesis that modulation of the gut microbiota in neonatal pigs receiving no treatment (control), intravenously administered antibiotics, or probiotics affects whole body nitrogen and amino acid turnover. We quantified whole body urea kinetics, threonine fluxes, and threonine disposal into protein, oxidation, and tissue protein synthesis with stable isotope techniques. Compared with controls, antibiotics reduced the number and diversity of bacterial species in the distal small intestine (SI) and colon. Antibiotics decreased plasma urea concentrations via decreased urea synthesis. Antibiotics elevated threonine plasma concentrations and turnover, as well as whole body protein synthesis and proteolysis. Antibiotics decreased protein synthesis rate in the proximal SI and liver but did not affect the distal SI, colon, or muscle. Probiotics induced a bifidogenic microbiota and decreased plasma urea concentrations but did not affect whole body threonine or protein metabolism. Probiotics decreased protein synthesis in the proximal SI but not in other tissues. In conclusion, modulation of the gut microbiota by antibiotics and probiotics reduced hepatic ureagenesis and intestinal protein synthesis, but neither altered whole body net threonine balance. These findings suggest that changes in amino acid and nitrogen metabolism resulting from antibiotic- or probiotic-induced shifts in the microbiota are localized to the gut and liver and have limited impact on whole body growth and anabolism in neonatal piglets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.