ArticleStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]2013
A validated survival score for breast cancer patients with metastatic spinal cord compression.
Article in Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The influence of immunohistochemistry-based subtypes on overall survival in breast cancer spine metastases: a systematic review and meta-analysis.BMC medicine · 2026Pooled it
- Predicting survival of de novo metastatic breast cancer in Asian women: systematic review and validation study.PloS one · 2014Pooled it
- Does Duration of Symptoms in Metastatic Spine Disease Affect Recovery and Outcomes? A Systematic Review and Meta-Analysis.Global spine journal · 2026Review
- Preoperative Function, Previous SERM Treatment, and Triple-Negative Tumor Status are Independently Associated With 3-Month Postoperative Function After Surgical Decompression of Metastatic Breast Cancer.HSS journal : the musculoskeletal journal of Hospital for Special Surgery · 2025Article
- Pulmonary Function in Patients with Solitary Spinal Metastases: A Hospital-Based Cross-Sectional Study.International journal of general medicine · 2023Article
- Review
- Article
- Prognostic factors and a new scoring system for survival of patients irradiated for bone metastases.BMC cancer · 2019Article
- Prognostic models for spinal metastatic disease: evolution of methodologies, limitations, and future opportunities.Annals of translational medicine · 2019Review
- Classification and scoring systems for metastatic spine tumors: a literature review.Spine surgery and related research · 2017Review
- A new instrument for estimation of survival in elderly patients irradiated for metastatic spinal cord compression from breast cancer.Radiation oncology (London, England) · 2015Article
- Molecular phenotype is associated with survival in breast cancer patients with spinal bone metastases.Clinical & experimental metastasis · 2015Article
- Metastatic spinal cord compression: a validated survival score for elderly patients.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2014Article
- Scoring system for prediction of metastatic spine tumor prognosis.World journal of orthopedics · 2014Review
- Breast cancer patients with metastatic spinal cord compression. Number of extraspinal organs involved by metastases influences survival.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2014Article
- Prognostic Factors for Bone Survival and Functional Outcomes in Patients With Breast Cancer Spine Metastases.Technology in cancer research & treatmentReview
- Validation of a Survival Score for Patients Receiving Radiosurgery or Fractionated Stereotactic Radiotherapy for 1 to 3 Brain Metastases.In vivo (Athens, Greece)Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo create a validated scoring system predicting survival of breast cancer patients with metastatic spinal cord compression (MSCC). PATIENTS AND
methodsOf 510 patients, one half were assigned to either the test or the validation group. In the test group, eight pretreatment factors (age, performance status, number of involved vertebrae, ambulatory status, other bone metastases, visceral metastases, interval from cancer diagnosis to radiotherapy of MSCC, time of developing motor deficits) plus the radiation regimen were retrospectively investigated. Factors significantly associated with survival in the multivariate analysis were included in the scoring system. The score for each factor was determined by dividing the 6-month survival rate (%) by ten. The total score was the sum of the scores for each factor.
resultsIn the multivariate analysis of the test group, performance status, ambulatory status, other bone metastases, visceral metastases, interval from cancer diagnosis to radiotherapy of MSCC, and time of developing motor deficits were significant for survival and included in the score. Total scores ranged from 30 to 50 points. In the test group, the 6-month survival rates were 12% for 30-35 points, 41% for 36-40 points, 74% for 41-45 points, and 98% for 46-50 points (p < 0.0001). In the validation group, the 6-month survival rates were 14%, 46%, 77%, and 99%, respectively (p < 0.0001).
conclusionThe survival rates of the validation group were similar to the test group. Therefore, this score was reproducible and can help when selecting the appropriate radiotherapy regimen for each patient taking into account her survival prognosis.
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