ArticleJournal of applied oral science : revista FOB
Decreased phagocytic function in neutrophils and monocytes from peripheral blood in periodontal disease.
Article in Journal of applied oral science : revista FOB. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Interaction of the Systemic Inflammatory State, Inflammatory Mediators, and the Oral Microbiome.Advances in experimental medicine and biology · 2025Review
- Assessing the Correlation of Periodontal Inflamed Surface Area (PISA) With Systemic Inflammatory Markers.Cureus · 2024Article
- Recovery of the Decreased Phagocytic Function of Peripheral Monocytes and Neutrophil Granulocytes following Cytoreductive Surgery in Advanced Stage Epithelial Ovarian Cancer.Medicina (Kaunas, Lithuania) · 2023Article
- The indicative role of inflammatory index in the progression of periodontal attachment loss.European journal of medical research · 2023Article
- The effect of the "Oral-Gut" axis on periodontitis in inflammatory bowel disease: A review of microbe and immune mechanism associations.Frontiers in cellular and infection microbiology · 2023Review
- Phagocytic activity of monocytes and neutrophils in patients with periodontitis, whether or not associated to type 2 diabetes.Acta odontologica latinoamericana : AOL · 2021Article
- Gingival crevicular fluid infiltrating CD14+ monocytes promote inflammation in periodontitis.Saudi journal of biological sciences · 2021Article
- Immunomodulation in the Treatment of Periodontitis: Progress and Perspectives.Frontiers in immunology · 2021Review
- Toll-like receptor-2 and -4 responses regulate neutrophil infiltration into the junctional epithelium and significantly contribute to the composition of the oral microbiota.Journal of periodontology · 2019Article
- Distal Consequences of Oral Inflammation.Frontiers in immunology · 2019Review
- Oral Neutrophils Characterized: Chemotactic, Phagocytic, and Neutrophil Extracellular Trap (NET) Formation Properties.Frontiers in immunology · 2019Article
- Is periodontitis a comorbidity of COPD or can associations be explained by shared risk factors/behaviors?International journal of chronic obstructive pulmonary disease · 2017Review
- Impaired neutrophil extracellular trap formation: a novel defect in the innate immune system of aged individuals.Aging cell · 2014Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledPhagocytosis by neutrophils and monocytes constitutes the main defense mechanism against bacterial challenges in periodontitis. Phagocytosis by neutrophils has already been evaluated, whereas phagocytic function of monocytes has hardly been addressed so far.
objectivesThe aim of this study was to assess phagocytosis by neutrophils and monocytes in periodontitis. MATERIAL AND
methodsThe sample included 30 subjects with severe periodontitis and 27 control subjects without periodontal disease. The phagocytic index (PhI) was calculated as the mean number of adhered/ingested Saccharomyces cerevisiae per phagocytozing monocyte or neutrophil multiplied by the percentage of phagocytes involved in phagocytosis.
resultsA significant reduction in phagocyte functions was observed in individuals with periodontitis. The median of PhI of neutrophils using nonsensitized S. cerevisiae was 3 for the control group, and 1.5 for the periodontitis group (p=0.01, Mann-Whitney test). The median of PhI of monocytes with non-sensitized S. cerevisiae was 26.13 for the control group, and 13.23 for the periodontitis group (p=0.03, Mann Whitney test). The median of PhI of monocytes assessed with sensitized S. cerevisiae was 97.92 for the control group and 60.1 for the periodontitis group (p=0.005, t-test).
conclusionThe data demonstrated a reduction in the function of phagocytes, suggesting a decrease in immune defenses in periodontitis.
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