ArticleAge (Dordrecht, Netherlands)2013
Metabolic syndrome in the offspring of centenarians: focus on prevalence, components, and adipokines.
Article in Age (Dordrecht, Netherlands), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- The relationship between lifestyle, night shift pattern, mental health and the trajectories of nurses' metabolic diseases: a cohort study of nurses.Frontiers in public health · 2026Article
- Weight of time: exploring the link between obesity and aging.Aging clinical and experimental research · 2025Review
- Bcl-xL overexpression in T cells preserves muscle mitochondrial structure and function and prevents frailty in old mice.Science advances · 2025Article
- Centenarians-the way to healthy vascular ageing and longevity: a review from VascAgeNet.GeroScience · 2025Review
- BMI, Blood Pressure, and Plasma Lipids among Centenarians and Their Offspring.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Dietary vitamin intake and risk of metabolic syndrome among centenarians in China.Experimental and therapeutic medicine · 2021Article
- Correlations between indices of dynamic components of ambulatory blood pressure and renal damage in elderly Chinese male with essential hypertension.Blood pressure monitoring · 2020Article
- Vitamin D in physiological and pathological aging: Lesson from centenarians.Reviews in endocrine & metabolic disorders · 2019Review
- Frequency of metabolic syndrome and associated factors in institutionalized elderly individuals.Clinical interventions in aging · 2018Article
- Age-Associated Decline in Dendritic Cell Function and the Impact of Mediterranean Diet Intervention in Elderly Subjects.Frontiers in nutrition · 2017Article
- Article
- Article
- Article
- Decreased epigenetic age of PBMCs from Italian semi-supercentenarians and their offspring.Aging · 2015Article
- Aging, arterial stiffness, and hypertension.Hypertension (Dallas, Tex. : 1979) · 2015Review
- Health status and 6 years survival of 552 90+ Italian sib-ships recruited within the EU Project GEHA (GEnetics of Healthy Ageing).Age (Dordrecht, Netherlands) · 2014Article
- Differential gene expression in ERα-positive and ERα-negative breast cancer cells upon leptin stimulation.Endocrine · 2013Article
- Oxidative stress and the ageing endocrine system.Nature reviews. Endocrinology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With aging, an increased prevalence of a clustering of metabolic abnormalities has been observed. These abnormalities include obesity, dyslipidemia, hypertension, and insulin resistance and are collectively known as metabolic syndrome (MetS), a low-grade, systemic, inflammatory condition associated with an increased risk of cardiovascular disease, diabetes, and other adverse health outcomes. A number of studies have demonstrated that centenarians' offspring have a significant survival advantage and a lower risk of developing the most important age-related diseases. They therefore represent one of the best models with which to study the familiar component of human longevity. The aim of this study was to determine if the offspring of centenarians (n = 265 subjects) showed a different prevalence of MetS in comparison to the offspring of non-long-lived parents (controls, n = 101 subjects). In addition, we assessed whether centenarians' offspring showed particular features of MetS and a distinct regulation of circulating adipokines, cytokines, and metabolic mediators. Although the prevalence of MetS was quite similar both in the offspring of centenarians and the controls, MetS-affected centenarians' offspring seemed healthier, more functionally fit, and had lower resistin levels. MetS prevalence did not change in centenarians' offspring across resistin, IGF-1, and resistin/IGF-1 ratio tertiles. On the other hand, in controls, MetS prevalence strongly increased across resistin tertiles and in the third resistin/IGF-1 ratio tertile, indicating a dramatic increase in MetS prevalence when the ratio between these two factors is unbalanced, with high levels of resistin and low levels of IGF-1.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.