ArticleMicrovascular research2013
Cutaneous microvascular dysfunction correlates with serum LDL and sLOX-1 receptor concentrations.
Article in Microvascular research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Effects of vehicle microdialysis solutions on cutaneous vascular responses to local heating.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Trial
- Women with a history of gestational diabetes mellitus have preserved sensory nerve-mediated dilatation in the cutaneous microvasculature.Experimental physiology · 2026Article
- Local apocynin improves acetylcholine- but not insulin-mediated vasodilation in the cutaneous microvasculature of women with a history of gestational diabetes.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Impaired microvascular insulin-dependent dilation in women with a history of gestational diabetes.American journal of physiology. Heart and circulatory physiology · 2024Article
- Protective and curative effects of unconjugated bilirubin on gene expression of LOX-1 and iNOS in the heart of rats receiving high-fat diet and low dose streptozotocin: a histomorphometric approach.Journal of inflammation (London, England) · 2024Article
- Malondialdehyde-Modified Low-Density Lipoprotein as a Predictor of Major Adverse Limb Events after Endovascular Therapy in Patients with Lower Extremity Arterial Disease.Journal of atherosclerosis and thrombosis · 2023Article
- Oxidative stress contributes to reductions in microvascular endothelial- and nitric oxide-dependent dilation in women with a history of gestational diabetes.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Women with a history of preeclampsia have preserved sensory nerve-mediated dilatation in the cutaneous microvasculature.Experimental physiology · 2022Article
- Involvement of Fatty Acids and Their Metabolites in the Development of Inflammation in Atherosclerosis.International journal of molecular sciences · 2022Review
- Local angiotensin-(1-7) administration improves microvascular endothelial function in women who have had preeclampsia.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Modulation of Nitric Oxide Synthases by Oxidized LDLs: Role in Vascular Inflammation and Atherosclerosis Development.International journal of molecular sciences · 2019Review
- Microvascular imaging of the skin.Physics in medicine and biology · 2019Review
- Alterations in endothelin type B receptor contribute to microvascular dysfunction in women who have had preeclampsia.Clinical science (London, England : 1979) · 2017Article
- Increased Angiotensin II Sensitivity Contributes to Microvascular Dysfunction in Women Who Have Had Preeclampsia.Hypertension (Dallas, Tex. : 1979) · 2017Article
- Association between soluble lectin-like oxidized low-density lipoprotein receptor 1 levels and coronary slow flow phenomenon.Archives of medical science : AMS · 2016Article
- LOX-1-Targeted Iron Oxide Nanoparticles Detect Early Diabetic Nephropathy in db/db Mice.Molecular imaging and biology · 2015Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The human cutaneous circulation is an accessible and representative regional circulation for investigating mechanisms of microvascular dysfunction, a systemic disease process occurring early in the pathogenesis of atherosclerosis. Elevated concentrations of low-density lipoproteins ([LDL]) are highly atherogenic and independently associated with the severity of coronary atherosclerosis through their actions on the lectin-like oxidized LDL receptors (LOX-1). We hypothesized that cutaneous microvascular dysfunction, as measured by a decrement in endothelial nitric oxide- (NO-) dependent vasodilation during local heating, would be correlated with serum [LDL], oxidized [LDL], and soluble LOX-1 receptors [sLOX-1]. Intradermal microdialysis fibers were placed in the skin of 53 otherwise healthy men and women (aged 52±8 years) whose serum [LDL] ranged from 72 to 233 mg/dL. Skin blood flow was measured by laser Doppler flowmetry over a local forearm skin site as it was heated (42°C) to induce sustained local vasodilation. After flux plateaued, L-NAME was infused to block endothelial NO synthase in order to determine the NO-dependent portion of the vasodilatory response. Data were normalized to maximal cutaneous vascular conductance (CVC). NO-dependent vasodilation was reduced as a linear function of [LDL] (R(2)=0.303, p<0.001), oxidized [LDL] (R(2)=0.214, p<0.001), and [sLOX-1] (R(2)=0.259, p=0.026) but was unrelated to high-density lipoprotein (HDL) concentration (R(2)=0.003, p=0.68). Hypercholesterolemia-induced microvascular dysfunction is related to various LDL markers and involves a reduction in NO-dependent vasodilation that appears to be a progressive process measurable in the skin microcirculation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.