Evidence map›Paper›PMID 23137790›Full record

ReviewVeterinary immunology and immunopathology2013

Type II heat-labile enterotoxins: structure, function, and immunomodulatory properties.

George Hajishengallis, Terry D Connell

Abstract readReview
In one paragraph

Review in Veterinary immunology and immunopathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. The diverse landscape of AB5-type toxins.Engineering microbiology · 2023
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Biological Toxins as the Potential Tools for Bioterrorism.International journal of molecular sciences · 2019
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

George HajishengallisUniversity of Pennsylvania School of Dental Medicine, Department of Microbiology, Philadelphia, PA 19104, USA. geoh@dental.upenn.edu
Terry D Connell

Funding

P. gingivalis as a keystone pathogenR01DE015254 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI HAJISHENGALLIS, GEORGIOS · 2004 to 2018
$4.6M
Oral Immunity and Adjuvant ReceptorsR01DE017138 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI HAJISHENGALLIS, GEORGIOS · 2006 to 2014
$3.8M
TYPE II Enterotoxins as Mucosal ImmunomodulatorsR01DE013833 · NIDCR · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI CONNELL, TERRY D. · 2001 to 2010
$3.2M
Novel mechanisms and 'complement-ary' therapy in periodontitisR01DE021685 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI HAJISHENGALLIS, GEORGIOS · 2012 to 2016
$2.0M
Type II enterotoxins as mucosal immunomodulatorsR56DE013833 · NIDCR · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI CONNELL, TERRY D. · 2011 to 2011
$317k
NIDCR NIH HHS DE013833NIDCR NIH HHS DE015254NIDCR NIH HHS DE017138NIDCR NIH HHS R01 DE013833NIDCR NIH HHS R01 DE015254NIDCR NIH HHS R01 DE017138NIDCR NIH HHS R01 DE021685NIDCR NIH HHS R56 DE013833
6 · The paper itself

Abstract

The heat-labile enterotoxins (HLTs) of Escherichia coli and Vibrio cholerae are classified into two major types on the basis of genetic, biochemical, and immunological properties. Type I and Type II HLT have been intensively studied for their exceptionally strong adjuvant activities. Despite general structural similarities, these molecules, in intact or derivative (non-toxic) forms, display notable differences in their mode of immunomodulatory action. The molecular basis of these differences has remained largely uncharacterized until recently. This review focuses on the Type II HLTs and their immunomodulatory properties which depend largely on interactions with unique gangliosides and Toll-like receptors that are not utilized by the Type I HLTs.

Indexed as

Adjuvants, ImmunologicEnterotoxinsEscherichia coliGangliosidesImmunity, MucosalImmunologic FactorsToll-Like ReceptorsVibrio choleraeAdjuvants, ImmunologicEnterotoxinsGangliosidesImmunologic FactorsToll-Like Receptors

Identifiers

PMID23137790
PMCPMC3572302

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.