ArticleInternational wound journal2014
Transplantation of BMSCs expressing hVEGF165 /hBD3 promotes wound healing in rats with combined radiation-wound injury.
Article in International wound journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Smart and versatile biomaterials for cutaneous wound healing.Biomaterials research · 2023Review
- Ascorbic acid 2-glucoside preconditioning enhances the ability of bone marrow mesenchymal stem cells in promoting wound healing.Stem cell research & therapy · 2022Article
- Will mesenchymal stem cells be future directions for treating radiation-induced skin injury?Stem cell research & therapy · 2021Review
- Mesenchymal stem cell-based therapy for burn wound healing.Burns & trauma · 2021Review
- Wound healing and fibrosis: current stem cell therapies.Transfusion · 2019Article
- The effects of stem cells on burn wounds: a review.International journal of burns and trauma · 2019Review
- Transplantation of periodontal ligament cell sheets expressing human β‑defensin‑3 promotes anti‑inflammation in a canine model of periodontitis.Molecular medicine reports · 2017Article
- Effect of mesenchymal stem cells and platelet-derived growth factor on the healing of radiation induced ulcer in rats.Tissue engineering and regenerative medicine · 2016Article
- The Use of Stem Cells in Burn Wound Healing: A Review.BioMed research international · 2015Review
- Natural history of mesenchymal stem cells, from vessel walls to culture vessels.Cellular and molecular life sciences : CMLS · 2014Review
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Authors and funding
5 authors.
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Abstract
The combined radiation-wound injury is a refractory wound with decreased number or dysfunction of repairing cells and growth factors. This remains a challenge in clinical practice. The object of this study is to evaluate the therapeutic efficacy of a combination of human vascular endothelial growth factor 165 (hVEGF(165)) and human beta-defensin 3 (hBD3) in the treatment of such wounds. A plasmid-carrying hVEGF(165) gene and hBD3 gene was used to transfect rat bone-marrow-derived mesenchymal stem cells (BMSCs). The supernatant from the modified BMSCs significantly promoted the proliferation and cell migration of human endothelial cells and it also inhibited the growth of bacteria and fungus, demonstrating the successful expression of the transfected genes. The hVEGF(165)/hBD3-modified BMSCs were then injected into the sites of combined radiation-wound injury on rats. It demonstrated that wound-healing time was shortened significantly in the treated rats. The granulation tissue formation/maturation, skin appendage regeneration and collagen deposition were also improved significantly. Strong expression of hVEGF(165) and hBD3 was detected in the wound surface at early stage of the healing. The results indicate that topical transplantation of hVEGF(165)/hBD3-modified BMSCs promoted wound healing, and this gene therapy strategy presents a promising approach in the treatment of refractory wounds such as the combined radiation-wound injury.
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