ArticleBMC evolutionary biology2012
Adaptive evolution of the chrysanthemyl diphosphate synthase gene involved in irregular monoterpene metabolism.
Article in BMC evolutionary biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 31 citations in OpenAlex.
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- Identification of LecRLK gene family in Cerasus humilis through genomic-transcriptomic data mining and expression analyses.PloS one · 2021Article
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- Draft genome of Tanacetum cinerariifolium, the natural source of mosquito coil.Scientific reports · 2019Article
- Evolutionary Analysis of Plastid Genomes of SevenInternational journal of molecular sciences · 2018Article
- Modification of chrysanthemum odour and taste with chrysanthemol synthase induces strong dual resistance against cotton aphids.Plant biotechnology journal · 2018Article
- Duplication and diversification of lectin receptor-like kinases (LecRLK) genes in soybean.Scientific reports · 2018Article
- Origin and diversification of leucine-rich repeat receptor-like protein kinase (LRR-RLK) genes in plants.BMC evolutionary biology · 2017Article
- Divergence and adaptive evolution of the gibberellin oxidase genes in plants.BMC evolutionary biology · 2015Article
- Chrysanthemyl diphosphate synthase operates in planta as a bifunctional enzyme with chrysanthemol synthase activity.The Journal of biological chemistry · 2014Article
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5 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundChrysanthemyl diphosphate synthase (CDS) is a key enzyme in biosynthetic pathways producing pyrethrins and irregular monoterpenes. These compounds are confined to plants of the tribe Anthemideae of the Asteraceae, and play an important role in defending the plants against herbivorous insects. It has been proposed that the CDS genes arose from duplication of the farnesyl diphosphate synthase (FDS) gene and have different function from FDSs. However, the duplication time toward the origin of CDS and the evolutionary force behind the functional divergence of the CDS gene are still unknown.
resultsTwo duplication events were detected in the evolutionary history of the FDS gene family in the Asteraceae, and the second duplication led to the origin of CDS. CDS occurred after the divergence of the tribe Mutisieae from other tribes of Asteraceae but before the birth of the Anthemideae tribe. After its origin, CDS accumulated four mutations in sites homologous to the substrate-binding and catalysis sites of FDS. Of these, two sites were involved in the binding of the nucleophilic substrate isopentenyl diphosphate in FDS. Maximum likelihood analyses showed that some sites in CDS were under positive selection and were scattered throughout primary sequences, whereas in the three-dimensional structure model they clustered in the large central cavity.
conclusionPositive selection associated with gene duplication played a major role in the evolution of CDS.
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