ArticleAlcoholism, clinical and experimental research2013
Preliminary evidence for a gene-environment interaction in predicting alcohol use disorders in adolescents.
Article in Alcoholism, clinical and experimental research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Pooled it
- Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts.Behavior genetics · 2016Pooled it
- The effects of alcohol on the pharmacokinetics and pharmacodynamics of the selective mu-opioid receptor antagonist GSK1521498 in healthy subjects.Journal of clinical pharmacology · 2013Trial
- Childhood family environment and μ-opioid receptor availability in vivo in adulthood.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- OPRM1 Gene Polymorphism in Women with Alcohol Use Disorder.International journal of molecular sciences · 2024Article
- Peer-elicited alcohol craving in adolescents and emerging adults: Bridging the laboratory and natural environment.Alcohol, clinical & experimental research · 2023Article
- Neurobiology and the Treatment of Alcohol Use Disorder: A Review of the Evidence Base.Substance abuse and rehabilitation · 2023Review
- Parent and Adolescent Reports of Parental Monitoring and Sources of Parental Knowledge are Linked to Cannabis Use and Symptom Development in Adolescents.Cannabis (Albuquerque, N.M.) · 2022Article
- Associations between pre-adolescents' cognitive responses to alcohol-related cues, maternal drinking, and direct exposure to alcohol.Alcohol (Fayetteville, N.Y.) · 2021Article
- Bi-directional Acceleration of Alcohol Use and Opioid Use Disorder.Journal of drug and alcohol research · 2019Article
- Intergenerational Continuity in Substance Abuse: Does Offspring's Friendship Network Make a Difference?The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2018Article
- A systematic review: Candidate gene and environment interaction on alcohol use and misuse among adolescents and young adults.The American journal on addictions · 2018Review
- Interaction Between the μ-Opioid Receptor Gene and the Number of Heavy-Drinking Peers on Alcohol Use.Alcoholism, clinical and experimental research · 2017Article
- Genetic and psychosocial predictors of alcohol use trajectories among disaster-exposed adolescents.The American journal on addictions · 2017Article
- Affiliation with substance-using peers: Examining gene-environment correlations among parent monitoring, polygenic risk, and children's impulsivity.Developmental psychobiology · 2017Article
- Parent and peer influences on emerging adult substance use disorder: A genetically informed study.Development and psychopathology · 2017Article
- The Association of Low Parental Monitoring With Early Substance Use in European American and African American Adolescent Girls.Journal of studies on alcohol and drugs · 2015Article
- Association between Opioid Receptor mu 1 (OPRM1) Gene Polymorphisms and Tobacco and Alcohol Consumption in a Spanish Population.Bosnian journal of basic medical sciences · 2015Article
- Alcohol sensitivity moderates the indirect associations between impulsive traits, impaired control over drinking, and drinking outcomes.Journal of studies on alcohol and drugs · 2015Article
- Pharmacogenetics of OPRM1.Pharmacology, biochemistry, and behavior · 2014Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundEmerging research suggests that genetic influences on adolescent drinking are moderated by environmental factors. The present study builds on molecular-genetic findings by conducting the first analysis of gene-environment interactions in the association between a functional single nucleotide polymorphism (SNP) of the μ-opioid receptor (OPRM1) gene (A118G) and risk of developing an alcohol use disorder (AUD) during adolescence. Specifically, we tested whether variation in parenting practices or affiliation with deviant peers moderated the link between the OPRM1 gene and risk of an AUD.
methodsAdolescents reporting European ancestry (N = 104), ages 12 to 19 years (M = 15.60, SD = 1.77), were interviewed to ascertain AUD diagnoses, provided a DNA sample for genetic analyses, and completed measures of parental monitoring and deviant peer affiliation. Logistic regression was used to test the effects of environmental variables and their interactions with OPRM1 genotype as predictors of AUD diagnosis while controlling for age and sex.
resultsCase-control comparisons showed that the proportion of youth with an AUD (n = 18) significantly differed by genotype such that 33.3% of G allele carriers met criteria for an AUD compared to 10.8% of youth who were homozygous for the A allele (p = 0.006). The OPRM1 × parental monitoring (odds ratio = 0.16) and OPRM1 × deviant peer affiliation (odds ratio = 7.64) interactions were significant predictors of AUD risk, such that G allele carriers with high levels of deviant peer affiliation or lower levels of parental monitoring had the greatest likelihood of developing an AUD (p-values <0.01).
conclusionsThis study provides initial evidence that the association between the A118G SNP of the OPRM1 gene and risk of AUDs is moderated by modifiable factors. These results are limited, however, by the small sample size and require replication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.