ArticleKorean journal of pathology2012
ERG immunohistochemistry and clinicopathologic characteristics in Korean prostate adenocarcinoma patients.
Article in Korean journal of pathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Prevalence and clinical application ofAsian journal of andrologyPooled it
- A cross-sectional study of ERG expression and the relationship with clinicopathological features of Prostate cancer in Southwestern Uganda.Diagnostic pathology · 2024Article
- MiR-1271 Inhibits Cell Growth in Prostate Cancer by Targeting ERG.Pathology oncology research : POR · 2018Article
- Ethnicity and ERG frequency in prostate cancer.Nature reviews. Urology · 2018Review
- The Role of Immunohistochemical Analysis as a Tool for the Diagnosis, Prognostic Evaluation and Treatment of Prostate Cancer: A Systematic Review of the Literature.Frontiers in oncology · 2018Article
- Diverse Immunoprofile of Ductal Adenocarcinoma of the Prostate with an Emphasis on the Prognostic Factors.Journal of pathology and translational medicine · 2017Article
- Cancer Prognosis Defined by the Combined Analysis of 8q, PTEN and ERG.Translational oncology · 2016Article
- ERG oncoprotein expression in prostate carcinoma patients of different ethnicities.Molecular and clinical oncology · 2015Article
- Article
- Expression of c-MET in Invasive Meningioma.Journal of pathology and translational medicine · 2015Article
- Recurrent gene fusions in prostate cancer: their clinical implications and uses.Current urology reports · 2013Review
- ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients.Genes & development · 2013Article
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4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundTransmembrane protease serine 2-ETS related gene (TMPRSS2-ERG) gene fusion, the most common genetic alternation in prostate cancer, is associated with protein expression of the oncogene ERG. Recently, an immunohistochemical staining method using an anti-ERG antibody was shown to have a strong correlation with altered ERG protein expression.
methodsWe analyzed a total of 303 radical prostatectomy specimens (obtained from Korean prostate cancer cases) using a constructed tissue microarray and ERG immunohistochemical staining. Thereafter, we evaluated the association between ERG expression and clinicopathological factors.
resultsThe ERG-positive rate was 24.4% (74/303) and significantly higher ERG expression was observed in the subgroup with a lower Gleason score (p=0.004). Analysis of the histologic pattern of prostate adenocarcinomas revealed that tumors with discrete glandular units (Gleason pattern 3) displayed higher frequency of ERG expression (p=0.016). The ERG-positive rate was lower than that found (approximately 50%) in studies involving western populations. Other factors including age, tumor volume, initial protein-specific antigen level, a pathological stage and margin status were not significantly related with the ERG expression.
conclusionsERG immunohistochemical staining is significantly higher in tumors with well-formed glands and is associated with a lower Gleason score.
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