ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Short-term synaptic plasticity compensates for variability in number of motor neurons at a neuromuscular junction.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Compensation of the effects of temperature on a motor system in the crab,bioRxiv : the preprint server for biology · 2026Article
- Temperature and pH-dependent potassium currents of muscles of the stomatogastric nervous system of the crab,iScience · 2026Article
- Temperature and pH-dependent Potassium Currents of Muscles of the Stomatogastric Nervous System of the Crab,bioRxiv : the preprint server for biology · 2025Article
- Switching neuron contributions to second network activity.Journal of neurophysiology · 2024Article
- Heterogeneous receptor expression underlies non-uniform peptidergic modulation of olfaction in Drosophila.Nature communications · 2023Article
- Biophysical mechanism underlying compensatory preservation of neural synchrony over the adult lifespan.Communications biology · 2022Article
- Neuromodulation and Individuality.Frontiers in behavioral neuroscience · 2021Review
- TheFrontiers in neural circuits · 2021Review
- Article
- Homeostatic plasticity of excitability in crustacean central pattern generator networks.Current opinion in neurobiology · 2017Review
- Functional roles of short-term synaptic plasticity with an emphasis on inhibition.Current opinion in neurobiology · 2017Review
- The complexity of small circuits: the stomatogastric nervous system.Current opinion in neurobiology · 2016Review
- Feedback control of variability in the cycle period of a central pattern generator.Journal of neurophysiology · 2015Article
- Robust circuit rhythms in small circuits arise from variable circuit components and mechanisms.Current opinion in neurobiology · 2015Review
- Related neuropeptides use different balances of unitary mechanisms to modulate the cardiac neuromuscular system in the American lobster, Homarus americanus.Journal of neurophysiology · 2015Article
- Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We studied how similar postsynaptic responses are maintained in the face of interindividual variability in the number of presynaptic neurons. In the stomatogastric ganglion of the lobster, Homarus americanus, the pyloric (PY) neurons exist in variable numbers across animals. We show that each individual fiber of the stomach muscles innervated by PY neurons received synaptic input from all neurons present. We performed intracellular recordings of excitatory junction potentials (EJPs) in the muscle fibers to determine the consequences of differences in the number of motor neurons. Despite the variability in neuron number, the compound electrical response of muscle fibers to natural bursting input was similar across individuals. The similarity of total synaptic activation was not due to differences in the spiking activity of individual motor neurons across animals with different numbers of PY neurons. The amplitude of a unitary EJP in response to a single spike in a single motor neuron also did not depend on the number of PY neurons present. Consequently, the compound EJP in response to a single stimulus that activated all motor axons present was larger in individuals with more PY neurons. However, when axons were stimulated with trains of pulses mimicking bursting activity, EJPs facilitated more in individuals with fewer PY neurons. After a few stimuli, this resulted in depolarizations similar to the ones in individuals with more PY neurons. We interpret our findings as evidence that compensatory or homeostatic regulatory mechanisms can act on short-term synaptic dynamics instead of absolute synaptic strength.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.